製品の概要

  • 製品名Anti-DYRK2 antibody
    DYRK2 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to DYRK2
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment: MNDHLHVGSH AHGQIQVQQL FEDNSNKRTV LTTQPNGLTT VGKTGLPVVP ERQLDSIHRR QGSSTSLKSM EGMGKVKATP MTPEQAMKQY MQKLTAFEHH , corresponding to amino acids 1-100 of Human DYRK2

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab56363 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Role in the regulation of cellular growth and/or development. Regulates TP53 by phosphorylation on Ser-46 to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates.
    • 組織特異性Testis, after the onset of spermatogenesis.
    • 配列類似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
      Contains 1 protein kinase domain.
    • 翻訳後修飾Phosphorylated on serine/threonine residues.
    • 細胞内局在Cytoplasm. Nucleus. Translocates into the nucleus following DNA damage.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 1810038L18Rik antibody
      • Dual specificity tyrosine (Y) phosphorylation regulated kinase 2 antibody
      • Dual specificity tyrosine phosphorylation regulated kinase 2 antibody
      • Dual specificity tyrosine-phosphorylation-regulated kinase 2 antibody
      • DYRK2 antibody
      • DYRK2_HUMAN antibody
      • EC 2.7.12.1 antibody
      • FLJ21217 antibody
      • FLJ21365 antibody
      see all

    Anti-DYRK2 antibody 画像

    • Western blot against tagged recombinant protein immunogen using ab56363 DYRK2 antibody at 1ug/ml. Predicted band size of immunogen is 34 kDa
    • Western Blot analysis of DYRK2 expression in transfected 293T cell line by ab56363.

      Lane 1: DYRK2 transfected lysate(59.7 KDa).
      Lane 2: Non-transfected lysate.

    Anti-DYRK2 antibody (ab56363) 使用論文

    ab56363 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"