製品の概要

  • 製品名Anti-Dynorphin B antibody
    Dynorphin B 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Dynorphin B
  • 特異性This antibody blocks specifically with Dynorphin B 1-13. Cells are found in the paraventricular hypothalamic and the supraoptic nucleus in rat brain of colchicine treated 4% FA perfused tissue. Fibers are found in the lateral hypothalamus of both colchicine and normal rat brain of 4% FA perfused tissue.
  • アプリケーション適用あり: IHC-FoFr, IHC-Fr, RIAmore details
  • 種交差性
    交差種: Rat, Guinea pig, Hamster, Pig, Rhesus monkey
    交差が予測される動物種: Mouse, Cow, Human, Xenopus laevis
  • 免疫原

    Synthetic peptide:

    YGGFLRRQFKVVT

    , corresponding to amino acids 1-13 of Pig Dynorphin B. (Prodynorphin 228-240).

  • 特記事項This product should be stored undiluted. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: 1% BSA, Whole Serum, PBS
  • 精製度Whole antiserum
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab11135 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-FoFr Use at an assay dependent concentration. PubMed: 20206610
IHC-Fr 1/250 - 1/2500.
RIA 1/5000.

ターゲット情報

  • 機能Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
    Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
    Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
  • 関連疾患Defects in PDYN are the cause of spinocerebellar ataxia type 23 (SCA23) [MIM:610245]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria.
  • 配列類似性Belongs to the opioid neuropeptide precursor family.
  • 翻訳後修飾The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
  • 細胞内局在Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Beta-neoendorphin-dynorphin antibody
    • Big Dyn antibody
    • Dyn B antibody
    • Dyn-A17 antibody
    • Dyn-B antibody
    • Dynorphin A antibody
    • Dynorphin B antibody
    • Dynorphin B(1-13) antibody
    • Dynorphin B-29 antibody
    • Leumorphin antibody
    • PDYN antibody
    • PDYN_HUMAN antibody
    • Preprodynorphin antibody
    see all

Anti-Dynorphin B antibody (ab11135) 使用論文

This product has been referenced in:
  • Amrein I & Slomianka L A morphologically distinct granule cell type in the dentate gyrus of the red fox correlates with adult hippocampal neurogenesis. Brain Res 1328:12-24 (2010). IHC-FoFr . Read more (PubMed: 20206610) »

See 1 Publication for this product

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There are currently no Abreviews or Questions for ab11135.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"