Anti-Dynorphin A 抗体 (ab97798)
Key features and details
- Rabbit polyclonal to ProDynorphin
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-Dynorphin A antibody
ProDynorphin 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to ProDynorphin -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Recombinant fragment, corresponding to a region within amino acids 1-166 of Human Dynorphin A (AAH26334)
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ポジティブ・コントロール
- HepG2, MOLT4 or Raji lysates
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 89.99% PBS, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab97798の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 28 kDa.
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特記事項 |
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WB
1/500 - 1/3000. Predicted molecular weight: 28 kDa. |
ターゲット情報
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機能
Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
Leumorphin has a typical opiod activity and may have anti-apoptotic effect. -
関連疾患
Defects in PDYN are the cause of spinocerebellar ataxia type 23 (SCA23) [MIM:610245]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria. -
配列類似性
Belongs to the opioid neuropeptide precursor family. -
翻訳後修飾
The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 5173 Human
- Omim: 131340 Human
- SwissProt: P01213 Human
- Unigene: 22584 Human
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別名
- ADCA antibody
- Alpha neoendorphin antibody
- Beta neoendorphin antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab97798 は論文での使用が確認できていません。