製品の概要

  • 製品名Anti-Dynorphin A antibody
    Dynorphin A 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Dynorphin A
  • 特異性This antibody blocks with dynorphin 1-17 and 1-8 but not with other related peptides. Cells are found in the paraventricular and supraoptic nucleus and fibers are found in the lateral hypothalamus in rat brain of 4% FA perfused colchicine tissue.
  • アプリケーション適用あり: IHC-Fr, IHC-P, RIAmore details
  • 種交差性
    交差種: Mouse, Rat, Human, Pig, Rhesus monkey
    交差が予測される動物種: Guinea pig, Cow
  • 免疫原

    Synthetic peptide:

    YGGFLRRIRPKLKWDNQ

    (Pig).

  • 特記事項This product should be stored undiluted. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Whole Serum, PBS
  • 精製度Whole antiserum
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab11134 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-Fr 1/100 - 1/1500.
IHC-P Use at an assay dependent concentration. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
RIA 1/10000.

ターゲット情報

  • 関連性Dynorphins are a class of peptides produced by many different populations of neurons, which has some opiate like activity. It is thus classed as an endogenous opioid peptide. The dynorphins, which include dynorphin A, dynorphin B, alpha and beta neoendorphin, and big dynorphin, are all the products of a single gene, 'preprodynorphin'. Dynorphin is produced in many different parts of the brain, including the hypothalamus, the hippocampus and the spinal cord, and has many different physiological actions, depending upon its site of production. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. As such, it may help some individuals against addiction. Blocking dynorphin may help alleviate depression.
  • 細胞内局在Secreted
  • 参照データベース
  • 別名
    • Beta neoendorphin dynorphin antibody
    • Dyn A17 antibody
    • Dynorphin A antibody
    • PDYN antibody
    • Preprodynorphin antibody
    • Proenkephalin B antibody
    see all

Anti-Dynorphin A antibody (ab11134) 使用論文

This product has been referenced in:
  • Olsen J  et al. Intimate associations between the endogenous opiate systems and the growth hormone-releasing hormone system in the human hypothalamus. Neuroscience 258:238-45 (2014). Read more (PubMed: 24239719) »
  • Labuz D  et al. Immune cell-derived opioids protect against neuropathic pain in mice. J Clin Invest 119:278-86 (2009). IHC-Fr ; Mouse . Read more (PubMed: 19139563) »

See all 3 Publications for this product

Product Wall

Thank you for your call yesterday and for your question about these antibodies. I apologize for the delay getting back to you.

We have a general IHC protocol for FFPE sections that includes a section on antigen retrieval-

http://www...

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1. The serum is diluted in PBS, unfortunately we do not have the exact amount that is diluted, however we can estimate the specific antibody concentration to be 0.5-1.0mg/ml. 2. Unfortunately, I have been unsuccessful in locating information to su...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"