製品の概要

  • 製品名Dynasore
  • 製品の詳細
    Cell-permeable dynamin inhibitor
  • 生理活性の詳細Cell-permeable dynamin inhibitor, that blocks endocytosis. Non-competitively inhibits dynamin1, dynamin2 and mitochondrial dynamin GTPase activity. Selective over other small GTPases.
  • 精製度> 99%

製品の特性

  • 体系名3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide
  • 分子量322.31
  • 構造式Chemical Structure
  • 分子式C18H14N2O4
  • CAS 番号304448-55-3
  • 保存方法Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解性Soluble in DMSO to 100 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記Oc3ccc(/C=N/NC(=O)c1cc2ccccc2cc1O)cc3O
  • 由来

    Synthetic

  • 研究分野

    アプリケーション

    Our Abpromise guarantee covers the use of ab120192 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    アプリケーション Abreviews 特記事項
    Functional Studies Use at an assay dependent concentration.

    Dynasore 画像

    • ab66705 staining PAI1 in HeLa cells treated with dynasore (ab120192), by ICC/IF. Increase in PAI1 expression correlates with increased concentration of dynasore, as described in literature.
      The cells were incubated at 37°C for 6h in media containing different concentrations of ab120689 (dynasore) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab66705 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

    Dynasore (ab120192) 使用論文

    This product has been referenced in:

    See all 10 Publications for this product

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