製品の概要

  • 製品名Anti-Dynamin 2 antibody
    Dynamin 2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Dynamin 2
  • アプリケーション適用あり: IPmore details
    適用なし: WB
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Cow, Pig, Chimpanzee, Rhesus monkey, Gorilla, Chinese Hamster, Orangutan, Elephant
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 625-675 of Human Dynamin 2 (NP_001005360.1)

  • ポジティブ・コントロール
    • HeLa cell lysates

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab124251 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP Use at 2-10 µg/mg of lysate.
  • 追加情報Is unsuitable for WB.
  • ターゲット情報

    • 機能Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis.
    • 組織特異性Ubiquitously expressed.
    • 関連疾患Defects in DNM2 are a cause of centronuclear myopathy autosomal dominant (ADCNM) [MIM:160150]; also known as autosomal dominant myotubular myopathy. Centronuclear myopathies (CNMs) are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. CNMs comprise a wide spectrum of phenotypes, ranging from severe neonatal to mild late-onset familial forms. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.
      Defects in DNM2 are the cause of Charcot-Marie-Tooth disease dominant intermediate type B (CMTDIB) [MIM:606482]. Charcot-Marie-Tooth disease (CMT) is a clinically and genetically heterogeneous disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. CMTDIB is a form of Charcot-Marie-Tooth disease characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec.
    • 配列類似性Belongs to the dynamin family.
      Contains 1 GED domain.
      Contains 1 PH domain.
    • 細胞内局在Cytoplasm. Cytoplasm > cytoskeleton. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction > synapse. Microtubule-associated. Also found in the postsynaptic density of neuronal cells.
    • Information by UniProt
    • 参照データベース
    • 別名
      • CMT2M antibody
      • CMTDI1 antibody
      • CMTDIB antibody
      • DI CMTB antibody
      • Dnm2 antibody
      • DYN II antibody
      • DYN2 antibody
      • DYN2_HUMAN antibody
      • Dynamin II antibody
      • Dynamin-2 antibody
      • Dynamin2 antibody
      • DynaminII antibody
      • DYNII antibody
      see all

    Anti-Dynamin 2 antibody 画像

    • An antibody to Dynamin 2 at 1 µg/ml, staining Dynamin 2 in HeLa whole cell lysate immunoprecipitated using ab124251 at 6 µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with an exposure time of 30 seconds.

    Anti-Dynamin 2 antibody (ab124251) 使用論文

    ab124251 has not yet been referenced specifically in any publications.

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