製品の概要

  • 製品名Anti-DUOX2 antibody
    DUOX2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to DUOX2
  • 特異性The peptide immunogen has 78% homology to the DUOX1 protein. It is not known if this antibody will recognize DUOX1.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Rat, Human
    交差が予測される動物種: Mouse, Dog, Pig
  • 免疫原

    Synthetic peptide made from an internal portion of the human DUOX2 (within residues 400-500).

  • ポジティブ・コントロール
    • A549 whole cell lysate and rat lung homogenate.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.1% Sodium Azide
    Constituents: 30% Glycerol, PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab65813 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 2 µg/ml. Detects a band of approximately 175 kDa (predicted molecular weight: 175 kDa).

ターゲット情報

  • 機能Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
  • 組織特異性Expressed in colon, small intestine, duodenum and tracheal surface epithelial cells (at protein level). Expressed in thyrocytes. Also detected in kidney, liver, lung, pancreas, prostate, salivary glands, rectum and testis.
  • パスウェイHormone biosynthesis; thyroid hormone biosynthesis.
  • 関連疾患Defects in DUOX2 are a cause of thyroid dyshormonogenesis 6 (TDH6) [MIM:607200]. A disorder due to a defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.
  • 配列類似性In the N-terminal section; belongs to the peroxidase family.
    Contains 3 EF-hand domains.
    Contains 1 FAD-binding FR-type domain.
    Contains 1 ferric oxidoreductase domain.
  • 発生段階Widely expressed in fetal tissues.
  • 翻訳後修飾N-glycosylated.
  • 細胞内局在Apical cell membrane. Localizes to the apical membrane of epithelial cells.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Dual oxidase 2 antibody
    • Dual oxidase like domains 2 antibody
    • Dual oxidase2 antibody
    • DUOX2 antibody
    • DUOX2_HUMAN antibody
    • Flavoprotein NADPH oxidase antibody
    • Large NOX 2 antibody
    • LNOX2 antibody
    • Long NOX 2 antibody
    • NADH/NADPH thyroid oxidase p138 tox antibody
    • NADH/NADPH thyroid oxidase p138-tox antibody
    • NADPH oxidase/peroxidase DUOX2 antibody
    • NADPH thyroid oxidase 2 antibody
    • Nicotinamide adenine dinucleotide phosphate oxidase antibody
    • NOXEF2 antibody
    • p138 thyroid oxidase antibody
    • P138 TOX antibody
    • TDH6 antibody
    • THOX2 antibody
    • Thyroid oxidase 2 antibody
    see all

Anti-DUOX2 antibody 画像

  • Anti-DUOX2 antibody (ab65813) at 2 µg/ml + A549 whole cell lysate

    Predicted band size : 175 kDa
    Observed band size : 175 kDa
    Additional bands at : 50 kDa,58 kDa. We are unsure as to the identity of these extra bands.

Anti-DUOX2 antibody (ab65813) 使用論文

This product has been referenced in:
  • Sobhakumari A  et al. NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells. Toxicol Appl Pharmacol 272:736-745 (2013). Read more (PubMed: 23917044) »
  • Pettigrew CA  et al. DUOX enzyme activity promotes AKT signalling in prostate cancer cells. Anticancer Res 32:5175-81 (2012). Read more (PubMed: 23225414) »

See all 5 Publications for this product

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Thank you for your patience. I have received further information for these 2 antibodies: ab65813: The homology is 84.6%. Thus, crossreactivity with mouse might be likely. ab74099: homology is 64.3%. Mouse tissues have not yet been tested with ...

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