製品の概要

  • 製品名Anti-DsbA L antibody
  • 製品の詳細
    Rabbit polyclonal to DsbA L
  • 特異性ab92819 is specific for the ~25 kDa DsbA-L protein in Western blots of 3T3-L1 adipocytes and mouse white and brown adipose tissue lysate samples.
  • アプリケーション適用あり: WB, IHC-Frmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Recombinant full length Mouse DsbA L protein.

  • ポジティブ・コントロール
    • 3T3-L1 adipocytes and Mouse white and brown adipose tissue lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab92819 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/2000. Detects a band of approximately 25 kDa.
IHC-Fr Use at an assay dependent concentration.

ターゲット情報

  • 関連性Disulfide-bond-A oxidoreductase-like protein (DsbA-L, previously named as GST Kappa) is an adiponectin-interacting protein. DsbA-L is highly expressed in adipose tissue, and its expression level is negatively correlated with obesity in mice and humans. DsbA-L expression in 3T3-L1 adipocytes is stimulated by the insulin sensitizer rosiglitazone and inhibited by the inflammatory cytokine TNFalpha. Polymorphism of DsbA-L gene has recently been implicated in insulin secretion and body fat distribution. Overexpression of DsbA-L promotes adiponectin multimerization while suppressing DsbA-L expression by RNAi markedly and selectively reduces adiponectin levels and secretion in 3T3-L1 adipocytes. Recent studies identify DsbA-L as a key regulator for adiponectin biosynthesis.
  • 別名
    • DSBA like thioredoxin domain containing protein antibody

Anti-DsbA L antibody 画像

  • Anti-DsbA L antibody (ab92819) at 1/2000 dilution + Mouse adipose tissue

Anti-DsbA L antibody (ab92819) 使用論文

This product has been referenced in:
  • Jedrychowski MP  et al. Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in adipocytes. Mol Metab 4:758-70 (2015). Read more (PubMed: 26629401) »
  • Walker GE  et al. Pediatric obesity and vitamin D deficiency: a proteomic approach identifies multimeric adiponectin as a key link between these conditions. PLoS One 9:e83685 (2014). WB . Read more (PubMed: 24404137) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"