Anti-DRIP130 抗体 (ab70449)
製品の概要
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製品名Anti-DRIP130 antibody
DRIP130 一次抗体 製品一覧 -
製品の詳細Rabbit polyclonal to DRIP130
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由来種Rabbit
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アプリケーション適用あり: IPmore details
適用なし: WB -
種交差性交差種: Human
交差が予測される動物種: Mouse, Horse, Guinea pig, Dog, Chimpanzee, Ferret, Rhesus monkey, Gorilla, Orangutan, Zebra finch
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免疫原
Synthetic peptide, corresponding to a region between amino acids 400-450 of Human DRIP130 (SwissProt Q9ULK4)
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ポジティブ･コントロール
- Nuclear extract from HeLa cells
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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バッファーPreservative: 0.09% Sodium Azide
Constituents: 8mM PBS, 60mM Citrate, 150mM Tris, pH 7 to 8 -
Concentration information loading... -
精製度Immunogen affinity purified
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ポリ/モノポリクローナル
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アイソタイプIgG
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研究分野
関連製品
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Compatible Secondaries
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Positive Controls
アプリケーション
Our Abpromise guarantee covers the use of ab70449 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IP |
追加情報
IP: Use at 1 - 4 µg/mg of lysate.
Is unsuitable for WB.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Is unsuitable for WB.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
ターゲット情報
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機能Required for transcriptional activation subsequent to the assembly of the preinitiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.
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配列類似性Belongs to the Mediator complex subunit 23 family.
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細胞内局在Nucleus.
- Information by UniProt
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参照データベース
- Entrez Gene: 474822 Dog
- Entrez Gene: 9439 Human
- Entrez Gene: 70208 Mouse
- Omim: 605042 Human
- SwissProt: Q9ULK4 Human
- SwissProt: Q80YQ2 Mouse
- SwissProt: Q9CXY8 Mouse
- Unigene: 29679 Human
see all -
別名
- 130 kDa transcriptional co activator antibody
- 133 kDa transcriptional co activator antibody
- Activator recruited cofactor 130 kDa component antibody
see all
画像
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Immunoprecipitation - Anti-DRIP130 antibody (ab70449)Detection of Human DRIP130 by Immunoprecipitation in Nuclear extract (5 mg) from HeLa cells using ab70449 at 4 µg/5 mg extract. Detection: Coomassie stain.
参考文献
This product has been referenced in:
- Meyer KD et al. Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3. EMBO J 27:1447-57 (2008). Read more (PubMed: 18418385) »
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"