製品の概要

  • 製品名Anti-DR6 antibody [DR-6-04-EC]
    DR6 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [DR-6-04-EC] to DR6
  • 特異性The antibody immunoprecipitates overexpressed DR6 from DR6-transfected HEK/293 cells but has not been tested on endogenous DR6 therefore we do not guarantee it will work on endogenous DR6.
  • アプリケーション適用あり: Flow Cyt, IP, ICC/IFmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Fusion protein, corresponding to extracellular amino acids 42-335 of Human DR6, linked to the Fc portion of human IgG1.

  • ポジティブ・コントロール
    • overexpressed DR6 from DR6-transfected HEK/293 cells.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファーPreservative: 15mM Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • 精製度Protein A purified
  • ポリ/モノモノクローナル
  • クローン名DR-6-04-EC
  • アイソタイプIgG1
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab14740 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt Use a concentration of 1 µg/ml. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
IP Use at an assay dependent concentration. Antibody immunoprecipitates overexpressed DR6 from DR6-transfected HEK/293 cells.
ICC/IF Use at an assay dependent concentration.

ターゲット情報

  • 機能May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
  • 組織特異性Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.
  • 配列類似性Contains 1 death domain.
    Contains 4 TNFR-Cys repeats.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • TNFRSF 21 antibody
    • BM 018 antibody
    • BM018 antibody
    • CD358 antibody
    • Death receptor 6 antibody
    • DR 6 antibody
    • DR6 antibody
    • MGC31965 antibody
    • OTTHUMP00000039915 antibody
    • TNFR related death receptor 6 antibody
    • TNFRSF21 antibody
    • TNFRSF21 protein antibody
    • TNR21_HUMAN antibody
    • Tumor necrosis factor receptor superfamily member 21 antibody
    • Tumor necrosis factor receptor superfamily member 21 precursor antibody
    see all

Anti-DR6 antibody [DR-6-04-EC] 画像

  • ab14740 staining DR6 (green) in transiently transfected human Hela cells by ICC/IF. Nuclei were stained with DAPI (blue).

Anti-DR6 antibody [DR-6-04-EC] (ab14740) 使用論文

ab14740 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab14740.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"