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機能
May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
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組織特異性
Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.
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配列類似性
Contains 1 death domain.
Contains 4 TNFR-Cys repeats.
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細胞内局在
Membrane.
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Information by UniProt
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参照データベース
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別名
- TNFRSF 21 antibody
- BM 018 antibody
- BM018 antibody
- CD358 antibody
- Death receptor 6 antibody
- DR 6 antibody
- DR6 antibody
- MGC31965 antibody
- OTTHUMP00000039915 antibody
- TNFR related death receptor 6 antibody
- TNFRSF21 antibody
- TNFRSF21 protein antibody
- TNR21_HUMAN antibody
- Tumor necrosis factor receptor superfamily member 21 antibody
- Tumor necrosis factor receptor superfamily member 21 precursor antibody
see all