Anti-DR6 抗体 (ab8417)

製品の概要

• 製品名
  Anti-DR6 antibody
  DR6 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to DR6
• アプリケーション
  適用あり: WBmore details
• 種交差性
  交差種: Human
  
• 免疫原

  Synthetic peptide:

  QPEQKASNLIGTYRHC

  , corresponding to amino acids 42-56 of Human DR6. (Peptide available as ab8450.)

  Run BLAST with Run BLAST with
• ポジティブ･コントロール
  • HeLa and K562 whole cell lysates.

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Store at +4°C.
• バッファー
  PBS with 0.02% sodium azide
• Concentration information loading...
• 精製度
  IgG fraction
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Cell Biology
  • Apoptosis
  • Receptors
  • Death Receptors

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Immunizing Peptide (Blocking)
  • Human DR6 peptide (ab8450)
• Positive Controls
  • K562 whole cell lysate (ab7911)

アプリケーション

ターゲット情報

• 機能
  May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
• 組織特異性
  Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.
• 配列類似性
  Contains 1 death domain.
  Contains 4 TNFR-Cys repeats.
• 細胞内局在
  Membrane.

• Target information above from: UniProt accession O75509 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 27242 Human
  • Omim: 605732 Human
  • SwissProt: O75509 Human
  • Unigene: 443577 Human
• 別名
  • TNFRSF 21 antibody
  • BM 018 antibody
  • BM018 antibody

  • CD358 antibody
  • Death receptor 6 antibody
  • DR 6 antibody
  • DR6 antibody
  • MGC31965 antibody
  • OTTHUMP00000039915 antibody
  • TNFR related death receptor 6 antibody
  • TNFRSF21 antibody
  • TNFRSF21 protein antibody
  • TNR21_HUMAN antibody
  • Tumor necrosis factor receptor superfamily member 21 antibody
  • Tumor necrosis factor receptor superfamily member 21 precursor antibody

  see all

プロトコール

• Western blot protocols