製品の概要
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製品名Anti-DR6 antibody
DR6 一次抗体 製品一覧 -
製品の詳細Rabbit polyclonal to DR6
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由来種Rabbit
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アプリケーション適用あり: WBmore details
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種交差性交差種: Human
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免疫原
Synthetic peptide:
QPEQKASNLIGTYRHC
, corresponding to amino acids 42-56 of Human DR6. (Peptide available as ab8450.) -
ポジティブ･コントロール
- HeLa and K562 whole cell lysates.
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Store at +4°C.
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バッファーPBS with 0.02% sodium azide
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Concentration information loading... -
精製度DEAE-Chromatography
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ポリ/モノポリクローナル
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アイソタイプIgG
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研究分野
関連製品
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Compatible Secondaries
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Immunizing Peptide (Blocking)
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Positive Controls
アプリケーション
Our Abpromise guarantee covers the use of ab8417 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | 1/500 - 1/2000. Detects a band of approximately 68 kDa.Can be blocked with Human DR6 peptide (ab8450). |
ターゲット情報
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機能May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
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組織特異性Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.
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配列類似性Contains 1 death domain.
Contains 4 TNFR-Cys repeats. -
細胞内局在Membrane.
- Information by UniProt
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参照データベース
- Entrez Gene: 27242 Human
- Omim: 605732 Human
- SwissProt: O75509 Human
- Unigene: 443577 Human
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別名
- TNFRSF 21 antibody
- BM 018 antibody
- BM018 antibody
see all
画像
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Western blot - Anti-DR6 antibody (ab8417)All lanes : Anti-DR6 antibody (ab8417) at 1/500 dilution
Lane 1 : K562 whole cell lysate with absence of blocking peptide
Lane 2 : Raji whole cell lysate with absence of blocking peptide
Lane 3 : K562 whole cell lysate withHuman DR6 peptide (ab8450)
Lane 4 : Raji whole cell lysate withHuman DR6 peptide (ab8450)
Observed band size: 68 kDa (why is the actual band size different from the predicted?)
プロトコール
参考文献
This product has been referenced in:
- Klíma M et al. Functional analysis of the posttranslational modifications of the death receptor 6. Biochim Biophys Acta 1793:1579-87 (2009). WB ; Human . Read more (PubMed: 19654028) »
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"