製品の概要

  • 製品名Anti-DPYD antibody
    DPYD 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to DPYD
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow, Pig
  • 免疫原

    Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 144 of DPYD

  • ポジティブ・コントロール
    • H1299 whole cell lysate. A431, HeLa and HepG2 lysates

法規制情報

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab96496 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 111 kDa.

ターゲット情報

  • 機能Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
  • 組織特異性Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.
  • パスウェイAmino-acid biosynthesis; beta-alanine biosynthesis.
  • 関連疾患Defects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) [MIM:274270]; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing to semicoma.
  • 配列類似性Belongs to the dihydropyrimidine dehydrogenase family.
    Contains 3 4Fe-4S ferredoxin-type domains.
  • 細胞内局在Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • DHP antibody
    • DHPDHase antibody
    • Dihydropyrimidine dehydrogenase [NADP(+)] antibody
    • Dihydropyrimidine dehydrogenase [NADP+] antibody
    • Dihydropyrimidine dehydrogenase antibody
    • Dihydrothymine dehydrogenase antibody
    • Dihydrouracil dehydrogenase antibody
    • DPD antibody
    • DPYD antibody
    • DPYD_HUMAN antibody
    • MGC132008 antibody
    • MGC70799 antibody
    • OTTHUMP00000058954 antibody
    see all

Anti-DPYD antibody 画像

  • Anti-DPYD antibody (ab96496) at 1/500 dilution + H1299 whole cell lysate at 30 µg

    Predicted band size : 111 kDa

Anti-DPYD antibody (ab96496) 使用論文

ab96496 has not yet been referenced specifically in any publications.

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