製品の概要

  • 製品名
    DPN
  • 製品の詳細
    Potent, selective ERβ agonist
  • 生理活性の詳細
    Potent, selective ERβ agonist (EC50 values are 0.85 and 66 nM for ERβ and ERα, respectively). Cardioprotective and neuroprotective in vivo.
  • 精製度
    > 99%

法規制情報

製品の特性

参考文献

This product has been referenced in:
  • Morissette M  et al. Contribution of estrogen receptors alpha and beta to the effects of estradiol in the brain. J Steroid Biochem Mol Biol 108:327-38 (2008). Read more (PubMed: 17936613) »
  • Nikolic I  et al. Treatment with an estrogen receptor-beta-selective agonist is cardioprotective. J Mol Cell Cardiol 42:769-80 (2007). Read more (PubMed: 17362982) »
  • Carswell HV  et al. Neuroprotection by a selective estrogen receptor beta agonist in a mouse model of global ischemia. Am J Physiol Heart Circ Physiol 287:H1501-4 (2004). Read more (PubMed: 15155257) »
  • Meyers MJ  et al. Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J Med Chem 44:4230-51 (2001). Read more (PubMed: 11708925) »

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