Potent A1antagonist (Ki = 0.45 nM). Also exhibits antagonism at A2B receptors (pA2 = 7.16, for human A2B expressed in CHO cells).
Store at Room Temperature. The product can be stored for up to 12 months.
Soluble in ethanol to 10 mM and in DMSO to 5 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Alexander SP et al. Characterization of the human brain putative A2B adenosine receptor expressed in Chinese hamster ovary (CHO.A2B4) cells. Br J Pharmacol119:1286-90 (1996).
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Coates J et al. 1,3-Dipropyl-8-cyclopentyl xanthine (DPCPX): a useful tool for pharmacologists and physiologists? Gen Pharmacol25:387-94 (1994).
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Lohse MJ et al. 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX)--a selective high affinity antagonist radioligand for A1 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol336:204-10 (1987).
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