製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to DPAGT1
  • 特異性
    At least four isoforms of DPAGT1 are known to exist; ab117459 will recognize the two longest isoforms. ab117459 is predicted to not cross-react with UHRF1BP1.
  • アプリケーション
    適用あり: WB, ICC/IF, IHC-P, ICCmore details
  • 種交差性
    交差種: Mouse
    交差が予測される動物種: Human
  • 免疫原

    Synthetic peptide corresponding to 17 amino acids within a region near the N terminal of Human DPAGT1 (NP_001373).

  • ポジティブ・コントロール
    • Mouse kidney tissue lysate.
  • 特記事項
    Avoid repeated freeze thaw cycles and exposure to prolonged high temperatures.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • バッファー
    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • 特記事項(精製)
    ab117459 was purified by affinity chromatography via a peptide column.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG

アプリケーション

Our Abpromise guarantee covers the use of ab117459 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 46 kDa.
ICC/IF Use a concentration of 20 µg/ml.
IHC-P Use at an assay dependent concentration.
ICC Use a concentration of 2.5 µg/ml.

ターゲット情報

  • 機能
    Catalyzes the initial step in the synthesis of dolichol-P-P-oligosaccharides.
  • パスウェイ
    Protein modification; protein glycosylation.
  • 関連疾患
    Defects in DPAGT1 are the cause of congenital disorder of glycosylation type 1J (CDG1J) [MIM:608093]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
  • 配列類似性
    Belongs to the glycosyltransferase 4 family.
  • 細胞内局在
    Endoplasmic reticulum membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ALG7 antibody
    • AU021132 antibody
    • CDG Ij antibody
    • CDG1J antibody
    • CMS13 antibody
    • CMSTA2 antibody
    • D11S366 antibody
    • DGPT antibody
    • Dolichyl phosphate (UDP N acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc 1 P transferase) antibody
    • Dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 antibody
    • DPAGT1 antibody
    • DPAGT2 antibody
    • G1PT antibody
    • GlcNAc 1 P transferase 1 antibody
    • GlcNAc-1-P transferase antibody
    • Gnpta antibody
    • GPT antibody
    • GPT_HUMAN antibody
    • H2afx antibody
    • N-acetylglucosamine-1-phosphate transferase antibody
    • UAGT antibody
    • UDP GlcNAc:dolichyl phosphate N acetylglucosaminephosphotransferase antibody
    • UDP N acetylglucosamine dolichyl phosphate N acetylglucosaminephosphotransferase 1 antibody
    • UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase antibody
    • UGAT antibody
    see all

画像

  • Immunofluorescence of DPAGT1 in Human kidney tissue with ab117459 at 20 ug/mL.
  • All lanes : Anti-DPAGT1 antibody (ab117459) at 1 µg/ml

    Lane 1 : Mouse kidney tissue lysate
    Lane 2 : Mouse kidney tissue lysate with blocking peptide

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 46 kDa
  • Immunohistochemical analysis of Human kidney tissue, staining DPAGT1 with ab117459 at 2.5 µg/ml.

参考文献

ab117459 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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