Anti-DPAGT1/GPT 抗体 (ab117459)
Key features and details
- Rabbit polyclonal to DPAGT1/GPT
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
製品の概要
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製品名
Anti-DPAGT1/GPT antibody
DPAGT1/GPT 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to DPAGT1/GPT -
由来種
Rabbit -
特異性
At least four isoforms of DPAGT1/GPT are known to exist; ab117459 will recognize the two longest isoforms. ab117459 is predicted to not cross-react with UHRF1BP1.
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アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse -
免疫原
Synthetic peptide corresponding to Human DPAGT1/GPT (N terminal).
Database link: Q9H3H5 -
ポジティブ・コントロール
- WB: Mouse kidney tissue lysate.
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特記事項
Avoid repeated freeze thaw cycles and exposure to prolonged high temperatures.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
特記事項(精製)
ab117459 was purified by affinity chromatography via a peptide column. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab117459の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 46 kDa.
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特記事項 |
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 46 kDa. |
ターゲット情報
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機能
Catalyzes the initial step in the synthesis of dolichol-P-P-oligosaccharides. -
パスウェイ
Protein modification; protein glycosylation. -
関連疾患
Defects in DPAGT1 are the cause of congenital disorder of glycosylation type 1J (CDG1J) [MIM:608093]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. -
配列類似性
Belongs to the glycosyltransferase 4 family. -
細胞内局在
Endoplasmic reticulum membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 13478 Mouse
- SwissProt: P42867 Mouse
- Unigene: 18353 Mouse
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別名
- ALG7 antibody
- AU021132 antibody
- CDG Ij antibody
see all
画像
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (1)
ab117459 は 1 報の論文で使用されています。
- Tinklenberg JA et al. Myostatin inhibition using mRK35 produces skeletal muscle growth and tubular aggregate formation in wild type and TgACTA1D286G nemaline myopathy mice. Hum Mol Genet 27:638-648 (2018). PubMed: 29293963