製品の概要

  • 製品名
    Doxazosin mesylate
  • 製品の詳細
    Selective α1 adrenoceptor antagonist
  • 生理活性の詳細
    Selective α1 adrenoceptor antagonist (pKi values are 9.0, 8.5 and 8.4 at α1B, α1A and α1D receptors, respectively). Shows antihypertensive activity and induces apoptosis.
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Garrison JB & Kyprianou N Doxazosin induces apoptosis of benign and malignant prostate cells via a death receptor-mediated pathway. Cancer Res 66:464-72 (2006). Read more (PubMed: 16397262) »
  • González-Juanatey JR  et al. Doxazosin induces apoptosis in cardiomyocytes cultured in vitro by a mechanism that is independent of alpha1-adrenergic blockade. Circulation 107:127-31 (2003). Read more (PubMed: 12515754) »
  • Kenny BA  et al. Evaluation of the pharmacological selectivity profile of alpha 1 adrenoceptor antagonists at prostatic alpha 1 adrenoceptors: binding, functional and in vivo studies. Br J Pharmacol 118:871-8 (1996). Read more (PubMed: 8799556) »

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