製品の概要

  • 製品名Anti-DORFIN antibody
    DORFIN 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to DORFIN
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 383-413 of Human DORFIN (NP_056250.3, NP_904355.1).

  • ポジティブ・コントロール
    • NCI-H460 cell line lysates.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab123343 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 65 kDa.

ターゲット情報

  • 機能E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.
  • 組織特異性Widely expressed, with highest levels in heart. Ubiquitously expressed in the central nervous system.
  • パスウェイProtein modification; protein ubiquitination.
  • 配列類似性Belongs to the RBR family. RNF19 subfamily.
    Contains 1 IBR-type zinc finger.
    Contains 2 RING-type zinc fingers.
  • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Membrane. Cytoplasm > cytoskeleton > centrosome. Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AA032313 antibody
    • DKFZP566B1346 antibody
    • Dorfin antibody
    • Double ring finger protein antibody
    • Double ring-finger protein antibody
    • E3 ubiquitin-protein ligase RNF19A antibody
    • p38 antibody
    • p38 protein antibody
    • Ring finger protein 19 antibody
    • RING finger protein 19A antibody
    • Ring IBR ring domain containing protein Dorfin antibody
    • RN19A_HUMAN antibody
    • RNF19 antibody
    • RNF19A antibody
    • Ubce7ip2 antibody
    • UIP117 antibody
    • XYbp antibody
    see all

Anti-DORFIN antibody 画像

  • Anti-DORFIN antibody (ab123343) at 1/100 dilution + NCI-H460 cell line lysates at 35 µg

    Predicted band size : 65 kDa

Anti-DORFIN antibody (ab123343) 使用論文

ab123343 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab123343.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"