製品の概要

  • 製品名Anti-DORFIN antibody
    DORFIN 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to DORFIN
  • アプリケーション適用あり: IPmore details
    適用なし: WB
  • 種交差性
    交差種: Human
    交差が予測される動物種: Rabbit, Horse, Guinea pig, Cow, Dog, Pig, Chimpanzee, Ferret, Rhesus monkey, Gorilla, Elephant
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 600-650 of Human DORFIN (NP_056250.3).

  • ポジティブ・コントロール
    • HeLa whole cell lysates.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab113276 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP Use at 2-10 µg/mg of lysate.
  • 追加情報Is unsuitable for WB.
  • ターゲット情報

    • 機能E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.
    • 組織特異性Widely expressed, with highest levels in heart. Ubiquitously expressed in the central nervous system.
    • パスウェイProtein modification; protein ubiquitination.
    • 配列類似性Belongs to the RBR family. RNF19 subfamily.
      Contains 1 IBR-type zinc finger.
      Contains 2 RING-type zinc fingers.
    • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 細胞内局在Membrane. Cytoplasm > cytoskeleton > centrosome. Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients.
    • Information by UniProt
    • 参照データベース
    • 別名
      • AA032313 antibody
      • DKFZP566B1346 antibody
      • Dorfin antibody
      • Double ring finger protein antibody
      • Double ring-finger protein antibody
      • E3 ubiquitin-protein ligase RNF19A antibody
      • p38 antibody
      • p38 protein antibody
      • Ring finger protein 19 antibody
      • RING finger protein 19A antibody
      • Ring IBR ring domain containing protein Dorfin antibody
      • RN19A_HUMAN antibody
      • RNF19 antibody
      • RNF19A antibody
      • Ubce7ip2 antibody
      • UIP117 antibody
      • XYbp antibody
      see all

    Anti-DORFIN antibody 画像

    • Detection of DORFIN by Western Blot of Immunprecipitate.
      ab113276 at 1µg/ml staining DORFIN in HeLa whole cell lysate immunoprecipitated using ab113276 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
      Detection: Chemiluminescence with exposure time of 30 seconds.

    Anti-DORFIN antibody (ab113276) 使用論文

    ab113276 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab113276.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"