Anti-DRD5 抗体 (ab40656)
Key features and details
- Rabbit polyclonal to DRD5
- Suitable for: ICC/IF, Flow Cyt, WB
- Reacts with: Rat
- Isotype: IgG
製品の概要
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製品名
Anti-DRD5 antibody
DRD5 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to DRD5 -
由来種
Rabbit -
特異性
Cross-reacts with Human D5 Dopamine Receptor(Ac23-35) 100%, D5 Dopamine Receptor 80%. Does not cross react with other dopamine receptors (D1, D2, D3, D4).
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アプリケーション
適用あり: ICC/IF, Flow Cyt, WBmore details -
種交差性
交差種: Rat
交差が予測される動物種: Human, Gorilla -
免疫原
Synthetic peptide corresponding to Human DRD5 aa 23-35 (acetyl G23) conjugated to keyhole limpet haemocyanin (Cysteine residue).
Sequence: AcGNAVGGSAGAPP
Database link: P21918 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Lyophilized:Rehydrate the lyophilized antibody with 0.1 ml of PBS which contains 10 mg/ml BSA or with additional buffer (such as 10 mg/ml BSA in PBS) for more dilute antibody. -
保存方法
Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles. -
バッファー
Constituent: Whole serum -
Concentration information loading...
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精製度
Whole antiserum -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab40656の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ICC/IF |
Use at an assay dependent concentration.
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Flow Cyt | (1) |
Use at an assay dependent concentration.
ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody. |
WB | (1) |
Use at an assay dependent concentration. Predicted molecular weight: 53 kDa.
Blocking with 5% goat or donkey serum significantly reduces background as compared to BSA or milk. |
特記事項 |
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ICC/IF
Use at an assay dependent concentration. |
Flow Cyt
Use at an assay dependent concentration. ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody. |
WB
Use at an assay dependent concentration. Predicted molecular weight: 53 kDa. Blocking with 5% goat or donkey serum significantly reduces background as compared to BSA or milk. |
ターゲット情報
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機能
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. -
組織特異性
Neuron-specific, localized primarily within limbic regions of the brain. -
関連疾患
Defects in DRD5 are a cause of benign essential blepharospasm (BEB) [MIM:606798]. BEB is a primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness. -
配列類似性
Belongs to the G-protein coupled receptor 1 family. -
細胞内局在
Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 1816 Human
- Entrez Gene: 25195 Rat
- Omim: 126453 Human
- SwissProt: P21918 Human
- SwissProt: P25115 Rat
- Unigene: 380681 Human
- Unigene: 138110 Rat
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別名
- D(1B) dopamine receptor antibody
- D(5) dopamine receptor antibody
- D1 beta dopamine receptor antibody
see all
データシートおよび資料
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Datasheet download
参考文献 (2)
ab40656 は 2 報の論文で使用されています。
- Zhu Y et al. Dopamine D1 and D3 Receptors Modulate Heroin-Induced Cognitive Impairment through Opponent Actions in Mice. Int J Neuropsychopharmacol 20:257-268 (2017). PubMed: 27815417
- Reyes S et al. Variability in neuronal expression of dopamine receptors and transporters in the substantia nigra. Mov Disord 28:1351-9 (2013). PubMed: 23674405