製品の概要

  • 製品名Anti-Dopamine Receptor D3 antibody
    Dopamine Receptor D3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Dopamine Receptor D3
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region from the 3rd cytoplasmic domain of Human Dopamine Receptor D3 (NP_000787.2).

  • ポジティブ・コントロール
    • Human Brain, Cortex tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab115675 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 20 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
  • 組織特異性Brain.
  • 関連疾患Genetic variation in DRD3 is associated with essential tremor hereditary type 1 (ETM1) [MIM:190300]. ETM1 is the most common movement disorder. The main feature is postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant.
  • 配列類似性Belongs to the G-protein coupled receptor 1 family.
  • 翻訳後修飾Phosphorylated by GRK4 (GRK4-alpha and GRK4-gamma).
  • 細胞内局在Cell membrane. Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 3dopamine receptor antibody
    • D antibody
    • D(3) dopamine receptor antibody
    • Dopamine D3 receptor antibody
    • Dopamine receptor D3 antibody
    • DRD3 antibody
    • DRD3_HUMAN antibody
    • ETM1 antibody
    • FET1 antibody
    see all

Anti-Dopamine Receptor D3 antibody 画像

  • ab115675, at 20µg/ml, staining Dopamine Receptor D3 in Formalin-fixed, Paraffin-embedded Human Brain cortex tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Dopamine Receptor D3 antibody (ab115675) 使用論文

ab115675 has not yet been referenced specifically in any publications.

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