Anti-Dopamine beta Hydroxylase 抗体 (ab19353)
Key features and details
- Sheep polyclonal to Dopamine beta Hydroxylase
- Suitable for: ICC/IF, IHC-P
- Reacts with: Rat
- Isotype: n/a
製品の概要
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製品名
Anti-Dopamine beta Hydroxylase antibody
Dopamine beta Hydroxylase 一次抗体 製品一覧 -
製品の詳細
Sheep polyclonal to Dopamine beta Hydroxylase -
由来種
Sheep -
アプリケーション
適用あり: ICC/IF, IHC-Pmore details -
種交差性
交差種: Rat -
免疫原
Synthetic peptide corresponding to Rat Dopamine beta Hydroxylase aa 43-62.
Sequence:SEPPESPFPYHIPLDPEGTL
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特記事項
Detects human, bovine, rat and mouse DBH. It is not effective for immunohistochemistry in human brainThe Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
Preservative: 0.05% Sodium azide -
Concentration information loading...
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精製度
Whole antiserum -
ポリ/モノ
ポリクローナル -
研究分野
関連製品
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab19353の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ICC/IF |
1/5000.
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IHC-P |
1/2000.
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特記事項 |
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ICC/IF
1/5000. |
IHC-P
1/2000. |
ターゲット情報
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機能
Conversion of dopamine to noradrenaline. -
パスウェイ
Catecholamine biosynthesis; (R)-noradrenaline biosynthesis; (R)-noradrenaline from dopamine: step 1/1. -
関連疾患
Defects in DBH are the cause of dopamine beta-hydroxylase deficiency (DBH deficiency) [MIM:223360]; also known as norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction. -
配列類似性
Belongs to the copper type II ascorbate-dependent monooxygenase family.
Contains 1 DOMON domain. -
細胞内局在
Cytoplasmic vesicle > secretory vesicle lumen. Cytoplasmic vesicle > secretory vesicle > chromaffin granule lumen and Cytoplasmic vesicle > secretory vesicle membrane. Cytoplasmic vesicle > secretory vesicle > chromaffin granule membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 25699 Rat
- SwissProt: Q05754 Rat
- Unigene: 87166 Rat
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別名
- dbh antibody
- DBM antibody
- Dopamine beta hydroxylase antibody
see all
画像
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (8)
ab19353 は 8 報の論文で使用されています。
- Blokhin V et al. A New Method for the Visualization of Living Dopaminergic Neurons and Prospects for Using It to Develop Targeted Drug Delivery to These Cells. Int J Mol Sci 23:N/A (2022). PubMed: 35409040
- Cui K et al. Restoration of Noradrenergic Function in Parkinson's Disease Model Mice. ASN Neuro 13:17590914211009730 (2021). PubMed: 33940943
- Kim SM et al. Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass. Proc Natl Acad Sci U S A 117:14386-14394 (2020). PubMed: 32513693
- Luo Z et al. Effect of Electrical Stimulation of Cervical Sympathetic Ganglia on Intraocular Pressure Regulation According to Different Circadian Rhythms in Rats. Invest Ophthalmol Vis Sci 61:40 (2020). PubMed: 32976562
- Underhill SM et al. Amphetamine Stimulates Endocytosis of the Norepinephrine and Neuronal Glutamate Transporters in Cultured Locus Coeruleus Neurons. Neurochem Res 45:1410-1419 (2020). PubMed: 31912366
- Scott AL et al. Regulation of catecholamine release from the adrenal medulla is altered in deer mice (Peromyscus maniculatus) native to high altitudes. Am J Physiol Regul Integr Comp Physiol 317:R407-R417 (2019). PubMed: 31242021
- Mahata SK et al. Effect of heart failure on catecholamine granule morphology and storage in chromaffin cells. J Endocrinol 230:309-23 (2016). PubMed: 27402067
- Talavera-Adame D et al. Enhancement of embryonic stem cell differentiation promoted by avian chorioallantoic membranes. Tissue Eng Part A 15:3193-200 (2009). PubMed: 19364272