製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to DOK7
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 400 - 500 of Human DOK7.

    (Peptide available as ab90998.)

  • ポジティブ・コントロール
    • This antibody gave a positive signal in Human Skeletal Muscle Tissue Lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab77371 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Detects a band of approximately 53 kDa (predicted molecular weight: 53 kDa).

ターゲット情報

  • 機能
    Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK.
  • 組織特異性
    Preferentially expressed in skeletal muscle and heart Present in thigh muscle, diaphragm and heart but not in the liver or spleen (at protein level).
  • 関連疾患
    Defects in DOK7 are the cause of familial limb-girdle myasthenia autosomal recessive (LGM) [MIM:254300]; also called congenital myasthenic syndrome type 1B or CMS1B. LGM is a congenital myasthenic syndrome characterized by a typical 'limb girdle' pattern of muscle weakness with small, simplified neuromuscular junctions but normal acetylcholine receptor and acetylcholinesterase function.
  • 配列類似性
    Contains 1 IRS-type PTB domain.
    Contains 1 PH domain.
  • 細胞内局在
    Cell membrane. Cell junction > synapse. Accumulates at neuromuscular junctions.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Docking protein 7 antibody
    • DOK 7 antibody
    • DOK7 antibody
    • DOK7_HUMAN antibody
    • Downstream of tyrosine kinase 7 antibody
    • Protein Dok-7 antibody
    see all

画像

  • Anti-DOK7 antibody (ab77371) at 1 µg/ml + Human skeletal muscle tissue lysate - total protein (ab29330) at 10 µg

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 53 kDa
    Observed band size : 53 kDa
    Additional bands at : 40 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 2 minutes

プロトコール

参考文献

ab77371 has not yet been referenced specifically in any publications.

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