製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to DOK3
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide corresponding to a region within amino acids 434 and 496 of Human DOK3 (NP_079148).

  • ポジティブ・コントロール
    • A431 whole cell lysate

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab97297 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 53 kDa.

ターゲット情報

  • 機能
    DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate Abl function.
  • 組織特異性
    Expressed in spleen.
  • 配列類似性
    Belongs to the DOK family. Type A subfamily.
    Contains 1 IRS-type PTB domain.
    Contains 1 PH domain.
  • ドメイン
    PTB domain mediates receptor interaction.
  • 翻訳後修飾
    Constitutively tyrosine-phosphorylated.
    On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL kinase.
  • 細胞内局在
    Cytoplasm. Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Docking protein 3 antibody
    • DOK 3 antibody
    • DOK Like Protein antibody
    • Dok3 antibody
    • DOK3_HUMAN antibody
    • DOKL Pending antibody
    • Downstream of tyrosine kinase 3 antibody
    • p62 DOK Like Protein antibody
    see all

画像

  • Anti-DOK3 antibody (ab97297) at 1/1000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size : 53 kDa

プロトコール

参考文献

ab97297 has not yet been referenced specifically in any publications.

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