製品の概要

  • 製品名Anti-DOK3 antibody
    DOK3 一次抗体 製品一覧
  • 製品の詳細
    Mouse polyclonal to DOK3
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length human DOK3 protein (AAH04564.2; Q7L591-3).

  • ポジティブ・コントロール
    • Human liver tissue lysate, DOK3 transfected 293T cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab89327 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1 µg/ml. Predicted molecular weight: 53 kDa for isoform 1 and 36 kDa for isoform 2.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate Abl function.
    • 組織特異性Expressed in spleen.
    • 配列類似性Belongs to the DOK family. Type A subfamily.
      Contains 1 IRS-type PTB domain.
      Contains 1 PH domain.
    • ドメインPTB domain mediates receptor interaction.
    • 翻訳後修飾Constitutively tyrosine-phosphorylated.
      On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL kinase.
    • 細胞内局在Cytoplasm. Cell membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Docking protein 3 antibody
      • DOK 3 antibody
      • DOK Like Protein antibody
      • Dok3 antibody
      • DOK3_HUMAN antibody
      • DOKL Pending antibody
      • Downstream of tyrosine kinase 3 antibody
      • p62 DOK Like Protein antibody
      see all

    Anti-DOK3 antibody 画像

    • Anti-DOK3 antibody (ab89327) at 1 µg/ml + human liver tissue lysate at 50 µg

      Predicted band size : 36 kDa
      Observed band size : ~58 kDa (why is the actual band size different from the predicted?)
    • All lanes : Anti-DOK3 antibody (ab89327) at 1 µg/ml

      Lane 1 : DOK3 transfected 293T cell lysate
      Lane 2 : Non transfected lysate

      Lysates/proteins at 25 µg per lane.


      Predicted band size : 36 kDa
      Observed band size : 36 kDa

    Anti-DOK3 antibody (ab89327) 使用論文

    ab89327 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab89327.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"