製品の概要

  • 製品名Anti-DOK3 antibody
    DOK3 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to DOK3
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rat
  • 免疫原

    Synthetic peptide:

    TRERRKGPAPCDRP

    , corresponding to C terminal amino acids 483-490 of Human DOK3.

  • ポジティブ・コントロール
    • Human PBMC lysate.
  • 特記事項GenBank Accession Number – NP_079148.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab1357 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1 - 3 µg/ml. Detects a band of approximately 60-65 kDa (predicted molecular weight: 57 kDa).
    Peptide ELISA: antibody detection limit dilution >1/32000.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate Abl function.
    • 組織特異性Expressed in spleen.
    • 配列類似性Belongs to the DOK family. Type A subfamily.
      Contains 1 IRS-type PTB domain.
      Contains 1 PH domain.
    • ドメインPTB domain mediates receptor interaction.
    • 翻訳後修飾Constitutively tyrosine-phosphorylated.
      On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL kinase.
    • 細胞内局在Cytoplasm. Cell membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Docking protein 3 antibody
      • DOK 3 antibody
      • DOK Like Protein antibody
      • Dok3 antibody
      • DOK3_HUMAN antibody
      • DOKL Pending antibody
      • Downstream of tyrosine kinase 3 antibody
      • p62 DOK Like Protein antibody
      see all

    Anti-DOK3 antibody 画像

    • Anti-DOK3 antibody (ab1357) at 0.1 µg/ml + Human PBMC lysate (RIPA buffer) at 35 µg

      Predicted band size : 57 kDa


      Primary incubated for 1 hour. Detected by chemiluminescence.

    Anti-DOK3 antibody (ab1357) 使用論文

    This product has been referenced in:
    • Bounab Y  et al. Proteomic analysis of the SH2domain-containing leukocyte protein of 76 kDa (SLP76) interactome. Mol Cell Proteomics 12:2874-89 (2013). Mouse . Read more (PubMed: 23820730) »
    • Heckel T  et al. Src-dependent repression of ARF6 is required to maintain podosome-rich sealing zones in bone-digesting osteoclasts. Proc Natl Acad Sci U S A 106:1451-6 (2009). WB ; Mouse . Read more (PubMed: 19164586) »

    See all 2 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab1357.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"