製品の概要

  • 製品名Anti-DOK3 antibody
    DOK3 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to DOK3
  • アプリケーション適用あり: WB, ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow
  • 免疫原

    Synthetic peptide:

    TRERRKGPAPCDRP

    , corresponding to C terminal amino acids 484-496 of Human DOK3 (NP_079148.1).

  • ポジティブ・コントロール
    • Human PBMC lysate; Human placenta and spleen tissues.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab118823 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 53 kDa.
ELISA 1/64000.
IHC-P Use a concentration of 6.13 µg/ml.

ターゲット情報

  • 機能DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate Abl function.
  • 組織特異性Expressed in spleen.
  • 配列類似性Belongs to the DOK family. Type A subfamily.
    Contains 1 IRS-type PTB domain.
    Contains 1 PH domain.
  • ドメインPTB domain mediates receptor interaction.
  • 翻訳後修飾Constitutively tyrosine-phosphorylated.
    On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL kinase.
  • 細胞内局在Cytoplasm. Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Docking protein 3 antibody
    • DOK 3 antibody
    • DOK Like Protein antibody
    • Dok3 antibody
    • DOK3_HUMAN antibody
    • DOKL Pending antibody
    • Downstream of tyrosine kinase 3 antibody
    • p62 DOK Like Protein antibody
    see all

Anti-DOK3 antibody 画像

  • Anti-DOK3 antibody (ab118823) at 0.1 µg/ml + Human PBMC lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 53 kDa
  • ab118823, at 6.13 µg/ml, staining DOK3 in formalin fixed, paraffin embedded Human placenta tissue by Immunohistochemistry.
  • ab118823, at 6.13 µg/ml, staining DOK3 in formalin fixed, paraffin embedded Human spleen tissue by Immunohistochemistry.

Anti-DOK3 antibody (ab118823) 使用論文

ab118823 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"