製品の概要

  • 製品名Anti-DOK1 (phospho Y362) antibody
    DOK1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to DOK1 (phospho Y362)
  • 特異性ab75742 endogenous levels of DOK1 only when phosphorylated at tyrosine 362.
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    A Synthetic phosphopeptide derived from human DOK1 around the phosphorylation site of tyrosine 362 (P-I-YP-D-E).

  • ポジティブ・コントロール
    • Human breast carcinoma tissue and extracts from Jurkat cells.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab75742 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 52 kDa.
IHC-P 1/50 - 1/100.

ターゲット情報

  • 機能DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
  • 組織特異性Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells.
  • 配列類似性Belongs to the DOK family. Type A subfamily.
    Contains 1 IRS-type PTB domain.
    Contains 1 PH domain.
  • ドメインThe PTB domain mediates receptor interaction.
  • 翻訳後修飾Constitutively tyrosine-phosphorylated.
    Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway.
  • 細胞内局在Cytoplasm and Cytoplasm > perinuclear region.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Docking protein 1 62kD antibody
    • Docking protein 1 antibody
    • DOK 1 antibody
    • DOK1 antibody
    • DOK1_HUMAN antibody
    • Downstream of tyrosine kinase 1 antibody
    • p62(dok) antibody
    • P62DOK antibody
    • pp62 antibody
    see all

Anti-DOK1 (phospho Y362) antibody 画像

  • ab75742, at a 1/50 dilution, staining DOK1 in paraffin embedded human breast carcinoma tissue by Immunohistochemistry in the absence (left image) or presence (right image) of the immunizing phospho peptide.
  • All lanes : Anti-DOK1 (phospho Y362) antibody (ab75742) at 1/500 dilution

    Lane 1 : Jurkat cell extracts with immunising peptide
    Lane 2 : Jurkat cell extracts


    Predicted band size : 52 kDa
    Observed band size : 52 kDa

Anti-DOK1 (phospho Y362) antibody (ab75742) 使用論文

ab75742 has not yet been referenced specifically in any publications.

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