製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to DOCK4
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Elephant
  • 免疫原

    Synthetic peptide, corresponding to a region within internal sequence amino acids 1725-1775 of Human DOCK4 (NP_055520.3).

  • ポジティブ・コントロール
    • Human Ovarian and Prostate Carcinoma tissues.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファー
    Preservative: 0.09% Sodium azide
    Constituents: 99% Tris buffered saline, 0.1% BSA
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • 特記事項(精製)
    ab111876 is affinity purified using an epitope specific to DOCK4 immobilized on solid support.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab111876 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能
    Involved in regulation of adherens junction between cells. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP.
  • 組織特異性
    Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary.
  • 配列類似性
    Belongs to the DOCK family.
    Contains 1 DHR-1 (CZH-1) domain.
    Contains 1 DHR-2 (CZH-2) domain.
    Contains 1 SH3 domain.
  • ドメイン
    The DHR-2 domain probably mediates the GEF activity.
  • 細胞内局在
    Endomembrane system.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Dedicator of cytokinesis protein 4 antibody
    • Dock4 antibody
    • DOCK4_HUMAN antibody
    • KIAA0716 antibody

画像

  • ab111876 at 1/250 dilution staining DOCK4 in Formalin-fixed, Paraffin-embedded Human ovarian carcinoma tissue by Immunohistochemistry. Detection: DAB staining.
  • ab111876 at 1/250 dilution staining DOCK4 in Formalin-fixed, Paraffin-embedded Human Prostate carcinoma tissue by Immunohistochemistry. Detection: DAB staining.

プロトコール

参考文献

ab111876 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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