Anti-DOCK1 抗体 (ab97325)

製品の概要

• 製品名Anti-DOCK1 antibody
  DOCK1 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to DOCK1
• アプリケーション適用あり: ICC/IF, WB, IHC-Pmore details
• 種交差性
  交差種: Human
  
• 免疫原

  Synthetic peptide corresponding to a region within amino acids 1852 and 1865 of Human DOCK1 (NP_001371).

  Run BLAST with Run BLAST with
• ポジティブ･コントロール
  • WB: 293T whole cell lysate; HeLaS3 cell lysate ICC/IF: A431 cells IHC-P: Lung CA

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• バッファーPreservative: 0.01% Thimerosal (merthiolate)
  Constituents: 20% Glycerol, 0.1% BSA, PBS, pH 7
• Concentration information loading...
• 精製度Immunogen affinity purified
• ポリ/モノポリクローナル
• アイソタイプIgG
• 研究分野
  • Cell Biology
  • Apoptosis
  • Phagocytosis

  • Signal Transduction
  • Signaling Pathway
  • G Protein Signaling
  • Small G Proteins
  • Regulators

  • Metabolism
  • Pathways and Processes
  • Metabolism processes
  • Apoptosis

  • Cancer
  • Cell Death
  • Apoptosis
  • Phagocytosis

  • Cancer
  • Cell Death
  • Apoptosis
  • Metabolism

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

アプリケーション

ターゲット情報

• 機能Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.
• 組織特異性Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon.
• 配列類似性Belongs to the DOCK family.
  Contains 1 DHR-1 (CZH-1) domain.
  Contains 1 DHR-2 (CZH-2) domain.
  Contains 1 SH3 domain.
• ドメインThe DHR-2 domain is necessary and sufficient for the GEF activity.
• 細胞内局在Cytoplasm. Membrane. Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-triphosphate.

• Target information above from: UniProt accession Q14185 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 1793 Human
  • Omim: 601403 Human
  • SwissProt: Q14185 Human
  • Unigene: 159195 Human
  • Unigene: 645702 Human
• 別名
  • 180 kDa protein downstream of CRK antibody
  • Ced5 antibody
  • Dedicator of Cytokinesis 1 antibody

  • Dedicator of cytokinesis protein 1 antibody
  • DOCK 1 antibody
  • DOCK 180 antibody
  • DOCK1 antibody
  • DOCK1_HUMAN antibody
  • DOCK180 antibody

  see all