製品の概要

  • 製品名DNMT1 Inhibitor Screening Assay Kit
    DNMT1 キット 製品一覧
  • アッセイタイプEnzyme activity
  • 全工程の試験時間
    3h 00m
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: all Mammals
  • 製品の概要

    DNMT1 (DNA (cytosine-5)-methyltransferase 1) belongs to the DNMT family, responsible for methylation of CpG islands in the genome. DNMT1 preferably methylates cytosines located in hemimethylated DNA and it associates with DNA replication sites in S-phase. The selective inhibition of DNMT1 may lead to demethylation and expression of silenced tumor suppressor genes. Thus, the selective DNMT1 inhibitors could be a new addition to cancer therapeutic agents.


    Abcam's DNMT1 Inhibitor Screening Assay Kit (ab113465) allows the user to selectively screen DNMT1 inhibitors quickly. The kit is ready-to-use and provides all the essential components needed to carry out a successful DNMT1 activity/inhibitor screening experiment without the need for radioactivity or any special equipment.


    Not sure if this is the right product for you? Check out our DNMT Product Guide for help.

  • 特記事項

    It might be necessary to purchase DNMT1 enzyme - we recommend Recombinant human DNMT1 protein (ab198109).

  • アプリケーション適用あり: Functional Studiesmore details

製品の特性

    アプリケーション

    Our Abpromise guarantee covers the use of ab113465 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    アプリケーション Abreviews 特記事項
    Functional Studies Use at an assay dependent concentration.

    DNMT1 Inhibitor Screening Assay Kit 画像

    • Recombinant DNMT1 was incubated with substrate and inhibitors. DNMT1 activity was measured using ab113465 in the presence or absence of inhibitors.

    プロトコール

    DNMT1 Inhibitor Screening Assay Kit (ab113465) 使用論文

    This product has been referenced in:
    • Tong Z  et al. Age-related formaldehyde interferes with DNA methyltransferase function, causing memory loss in Alzheimer's disease. Neurobiol Aging 36:100-10 (2015). Read more (PubMed: 25282336) »

    See 1 Publication for this product

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    There are currently no Abreviews or Questions for ab113465.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"