製品の概要

  • 製品名Anti-DNAJC2 antibody
    DNAJC2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to DNAJC2
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a sequence between internal sequence amino acids 233-263 of Human DNAJC2.

  • ポジティブ・コントロール
    • Mouse Neuro 2a cell line lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab103238 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 72 kDa.

ターゲット情報

  • 機能Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.
  • 組織特異性Widely expressed.
  • 配列類似性Contains 1 J domain.
    Contains 2 SANT domains.
  • ドメインThe ZRF1-UBD region specifically recognizes and binds H2AK119ub. The ZRF1-UBD region is also involved in protein-protein interactions with other proteins, suggesting that it may be masked by some regulator, thereby preventing its association with H2AK119ub.
  • 翻訳後修飾Phosphorylated in M (mitotic) phase.
  • 細胞内局在Nucleus. Cytoplasm > cytosol.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AU020218 antibody
    • DnaJ (Hsp40) homolog subfamily C member 2 antibody
    • DnaJ homolog subfamily C member 2 antibody
    • Dnajc2 antibody
    • DNJC2_HUMAN antibody
    • M phase phosphoprotein 11 antibody
    • M-phase phosphoprotein 11 antibody
    • MGC105894 antibody
    • MIDA1 antibody
    • MPHOSPH11 antibody
    • MPP11 antibody
    • OTTMUSP00000031226 antibody
    • ZRF1 antibody
    • Zrf2 antibody
    • ZUO1 antibody
    • Zuotin related factor 1 antibody
    • Zuotin related factor 2 antibody
    • Zuotin-related factor 1 antibody
    see all

Anti-DNAJC2 antibody 画像

  • Anti-DNAJC2 antibody (ab103238) at 1/100 dilution + Mouse Neuro-2a cell line lysate at 35 µg

    Predicted band size : 72 kDa

Anti-DNAJC2 antibody (ab103238) 使用論文

ab103238 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab103238.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"