製品の概要

  • 製品名Anti-DNAJB6 antibody
    DNAJB6 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to DNAJB6
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Dog, Drosophila melanogaster
  • 免疫原

    A synthetic peptide corresponding to a region of Human DNAJB6

  • ポジティブ・コントロール
    • Fetal muscle lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab75196 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Detects a band of approximately 36, 50 kDa (predicted molecular weight: 36 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

ELISA titre using peptide based assay 1:312500.

ターゲット情報

  • 機能Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.
  • 組織特異性Widely expressed. Highest levels in testis and brain, and lower levels in heart, spleen, intestine, ovary, placenta, lung, kidney, pancreas, thymus, prostate, skeletal muscle, liver and leukocytes. In testis, expressed in germ cells in the earlier stages of differentiation pathway as well as in spermatids. In brain, expressed at a higher level in hippocampus and thalamus and a lower level in amygdala, substantia nigra, corpus callosum and caudate nucleus.
  • 関連疾患Limb-girdle muscular dystrophy 1E
  • 配列類似性Contains 1 J domain.
  • ドメインThe antiaggregation activity of isoform B resides in the serine-rich region and the C-terminus.
  • 細胞内局在Cytoplasm, perinuclear region. Nucleus. Cytoplasm, myofibril, sarcomere, Z line.
  • Information by UniProt
  • 参照データベース
  • 別名
    • DJ4 antibody
    • DnaJ antibody
    • DnaJ (Hsp40) homolog subfamily B member 6 antibody
    • DNAJ B6 antibody
    • DnaJ homolog subfamily B member 6 antibody
    • DnaJ like 2 protein antibody
    • DNAJB6 antibody
    • DNJB6_HUMAN antibody
    • Heat shock protein J2 antibody
    • HHDJ1 antibody
    • HSJ-2 antibody
    • HSJ2 antibody
    • LGMD1E antibody
    • MRJ antibody
    • MSJ-1 antibody
    • MSJ1 antibody
    see all

Anti-DNAJB6 antibody 画像



  • Predicted band size : 36 kDa
    Western blot analysis of Human adult placenta tissue lysate labeling DNAJB6 with ab75196 at 1.0µg/ml.
  • Anti-DNAJB6 antibody (ab75196) at 1 µg/ml + Fetal muscle lysate at 10 µg

    Predicted band size : 36 kDa
    Observed band size : 36,50 kDa (why is the actual band size different from the predicted?)

Anti-DNAJB6 antibody (ab75196) 使用論文

ab75196 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"