製品の概要

  • 製品名Anti-DNAH5 antibody
    DNAH5 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to DNAH5
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Horse, Rhesus monkey, Gorilla
  • 免疫原

    Recombinant fragment : NFDTLTSSIN ARANALLLTT VTRKKKETEM LGEEARELLS HFNHQNMDAL LKVTRNTLEA IRKRIHSSHT INFRDSNSAS NMKQNSLP, corresponding to internal sequence amino acids 921-1008 of Human DNAH5 (Q8TE73)

  • ポジティブ・コントロール
    • Human fallopian tube tissue.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーpH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab122390 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/10 - 1/20. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles.
  • 関連疾患Defects in DNAH5 are the cause of primary ciliary dyskinesia type 3 (CILD3) [MIM:608644]. CILD3 is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
    Defects in DNAH5 are a cause of Kartagener syndrome (KTGS) [MIM:244400]. KTGS is an autosomal recessive disorder characterized by the association of primary ciliary dyskinesia with situs inversus. Clinical features include recurrent respiratory infections, bronchiectasis, infertility, and lateral transposition of the viscera of the thorax and abdomen. The situs inversus is most often total, although it can be partial in some cases (isolated dextrocardia or isolated transposition of abdominal viscera).
  • 配列類似性Belongs to the dynein heavy chain family.
  • ドメインDynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.
  • 細胞内局在Cytoplasm > cytoskeleton > cilium axoneme.
  • Information by UniProt
  • 参照データベース
  • 別名
    • axonemal antibody
    • Axonemal beta dynein heavy chain 5 antibody
    • Ciliary dynein heavy chain 5 antibody
    • DNAH 5 antibody
    • Dnah5 antibody
    • DNAHC5 antibody
    • DYH5_HUMAN antibody
    • Dynein heavy chain 5 antibody
    • Dynein heavy chain 5, axonemal antibody
    • HL1 antibody
    • KIAA1603 antibody
    see all

Anti-DNAH5 antibody 画像

  • ab122390 at 1/10 staining DNAH5 in formalin fixed paraffin embedded Human fallopian tube using immunohistochemistry.

Anti-DNAH5 antibody (ab122390) 使用論文

ab122390 has not yet been referenced specifically in any publications.

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