Anti-DNA Polymerase iota 抗体 - N-terminal (ab104319)


  • 製品名Anti-DNA Polymerase iota antibody - N-terminal
    DNA Polymerase iota 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to DNA Polymerase iota - N-terminal
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide designed within residues: PVVERLGFDE NFVDLTEMVE KRLQQLQSDE LSAVTVSGHV YNNQSINLLD, corresponding to N terminal amino acids 118 - 167 of Human DNA Polymerase iota (NP_009126).

  • ポジティブ・コントロール
    • Fetal lung lysate


  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • バッファーPreservative: None
    Constituents: PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野


Our Abpromise guarantee covers the use of ab104319 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 80 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • 機能Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
  • 組織特異性Ubiquitous. Highly expressed in testis.
  • 配列類似性Belongs to the DNA polymerase type-Y family.
    Contains 1 umuC domain.
  • ドメインThe catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity.
  • 細胞内局在Nucleus. Accumulates at replication forks after DNA damage.
  • Information by UniProt
  • 参照データベース
  • 別名
    • DNA polymerase iota antibody
    • Eta 2 antibody
    • Eta2 antibody
    • POLI antibody
    • POLI_HUMAN antibody
    • Polymerase (DNA directed) iota antibody
    • RAD 30B antibody
    • RAD30 homolog B antibody
    • RAD30, S. cerevisiae, homolog of antibody
    • RAD30B antibody
    • RAD3OB antibody
    see all

Anti-DNA Polymerase iota antibody - N-terminal 画像

  • Anti-DNA Polymerase iota antibody - N-terminal (ab104319) at 1 µg/ml + Human fetal lung lysate at 10 µg

    Predicted band size : 80 kDa

Anti-DNA Polymerase iota antibody - N-terminal (ab104319) 使用論文

ab104319 has not yet been referenced specifically in any publications.

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