製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to DMGDH
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    antigen sequence, corresponding to C terminal amino acids 776-859 (TLATDDVDPE GNESIWYNGK VVGNTTSGSY SYSIQKSLAF AYVPVQLSEV GQQVEVELLG KNYPAVIIQE PLVLTEPTRN RLQK) of Human DMGDH.

  • ポジティブ・コントロール
    • Human kidney tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab122336 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • パスウェイ
    Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 2/2.
  • 関連疾患
    Defects in DMGDH are the cause of DMGDH deficiency (DMGDHD) [MIM:605850]. DMGDHD is a disorder characterized by fish odor, muscle fatigue with increased serum creatine kinase. Biochemically it is characterized by an increase of N,N-dimethylglycine (DMG) in serum and urine.
  • 配列類似性
    Belongs to the GcvT family.
  • 細胞内局在
    Mitochondrion.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Dimethylglycine dehydrogenase antibody
    • Dimethylglycine dehydrogenase, mitochondrial antibody
    • Dmgdh antibody
    • M2GD_HUMAN antibody
    • ME2GLYDH antibody
    • mitochondrial antibody
    see all

画像

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human kidney tissue labelling DMGDH with ab122336. Staining shows strong cytoplasmic positivity in renal tubules.

プロトコール

参考文献

ab122336 has not yet been referenced specifically in any publications.

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