製品の概要

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab66390 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1.25 µg/ml. Detects a band of approximately 40 kDa (predicted molecular weight: 32 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA 1/1.5625e+006.
ChIP Use at an assay dependent concentration. PubMed: 22351765
CHIPseq Use at an assay dependent concentration. PubMed: 22351765

ターゲット情報

  • 機能Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.
  • 関連疾患Defects in DLX3 are a cause of trichodentoosseous syndrome (TDO) [MIM:190320]. TDO is an autosomal dominant syndrome characterized by enamel hypoplasia and hypocalcification with associated strikingly curly hair.
    Defects in DLX3 are the cause of amelogenesis imperfecta type 4 (AI4) [MIM:104510]; also known as amelogenesis imperfecta hypomaturation-hypoplastic type with taurodontism. AI4 is an autosomal dominant defect of enamel formation associated with enlarged pulp chambers.
  • 配列類似性Belongs to the distal-less homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AI4 antibody
    • Distal less homeo box 3 antibody
    • DLX 3 antibody
    • Dlx3 antibody
    • DLX3 distalless homeobox 3 antibody
    • DLX3_HUMAN antibody
    • Homeobox protein DLX 3 antibody
    • Homeobox protein DLX-3 antibody
    • Homeobox protein Dlx3 antibody
    • TDO antibody
    see all

Anti-DLX3 antibody - ChIP Grade 画像

  • Anti-DLX3 antibody - ChIP Grade (ab66390) at 1.25 µg/ml + Transfected 293T cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 32 kDa
    Observed band size : 40 kDa (why is the actual band size different from the predicted?)

Anti-DLX3 antibody - ChIP Grade (ab66390) 使用論文

This product has been referenced in:
  • Isaac J  et al. DLX3 regulates bone mass by targeting genes supporting osteoblast differentiation and mineral homeostasis in vivo. Cell Death Differ N/A:N/A (2014). Read more (PubMed: 24948010) »
  • Duverger O  et al. Neural crest deletion of Dlx3 leads to major dentin defects through down-regulation of Dspp. J Biol Chem 287:12230-40 (2012). ChIP, CHIPseq ; Mouse . Read more (PubMed: 22351765) »

See all 2 Publications for this product

Product Wall

I am sorry this product did not perform as stated on the datasheet and for the inconvenience this has caused. As requested, I have issued a free of charge replacement with the order number xxx.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"