製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to Dkk3
  • アプリケーション
    適用あり: WB, ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide:

    AAAALLGGEEI

    with a Cysteine residue linker, corresponding to C terminal amino acids 340-350 of Human Dkk3 (NP_037385.2).

  • ポジティブ・コントロール
    • Human brain cortex tissue; HEK293 lysate.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • バッファー
    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • 精製度
    Protein G purified
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab115869 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.03 - 0.1 µg/ml. Predicted molecular weight: 38 kDa.
ELISA 1/16000.
IHC-P Use a concentration of 5 µg/ml.

ターゲット情報

  • 機能
    Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
  • 組織特異性
    Highest expression in heart, brain, and spinal cord.
  • 配列類似性
    Belongs to the dickkopf family.
  • ドメイン
    The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
  • 翻訳後修飾
    N- and O-glycosylated.
  • 細胞内局在
    Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Dickkopf 3 antibody
    • Dickkopf 3 homolog (Xenopus laevis) antibody
    • Dickkopf 3 homolog antibody
    • Dickkopf homolog 3 antibody
    • Dickkopf related protein 3 antibody
    • Dickkopf related protein 3 Precursor antibody
    • Dickkopf WNT signaling pathway inhibitor 3 antibody
    • Dickkopf, Xenopus, homolog of, 3 antibody
    • Dickkopf-3 antibody
    • Dickkopf-related protein 3 antibody
    • Dickkopf3 antibody
    • DKK 3 antibody
    • Dkk-3 antibody
    • DKK3 antibody
    • DKK3_HUMAN antibody
    • hDkk 3 antibody
    • hDkk-3 antibody
    • hDkk3 antibody
    • Regulated in glioma antibody
    • REIC antibody
    • RIG antibody
    • RIG-like 5-6 antibody
    • RIG-like 7-1 antibody
    see all

Anti-Dkk3 antibody 画像

  • ab115869, at 5 µg/ml, staining Dkk3 in Formalin-fixed, Paraffin-embedded Human brain cortex by Immunohistochemistry.
  • Anti-Dkk3 antibody (ab115869) at 2 µg/ml + HEK293 lysate at 30 µg
    Developed using the ECL technique

    Predicted band size : 38 kDa

Anti-Dkk3 antibody (ab115869) 使用論文

ab115869 has not yet been referenced specifically in any publications.

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There are currently no Abreviews or Questions for ab115869.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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