製品の概要

  • 製品名Anti-DKK2 antibody
    DKK2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to DKK2
  • 特異性DKK2 fragments of ~55 kDa and ~28 kDa can also be detected in rat kidney tissue lysate
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide, surrounding amino acid 241 of Mouse DKK2

  • ポジティブ・コントロール
    • Lysate from Jurkat cells, 3T3 cells and rat kidney tissue

法規制情報

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファーPreservative: 0.01% Thimerosal (merthiolate)
    Constituents: 30% Glycerol, 0.5% BSA, PBS
  • Concentration information loading...
  • 精製度Protein A purified
  • 特記事項(精製)ab95274 is affinity purified.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab95274 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.5 - 4 µg/ml. Predicted molecular weight: 28 kDa.

ターゲット情報

  • 機能Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
  • 組織特異性Expressed in heart, brain, skeletal muscle and lung.
  • 配列類似性Belongs to the dickkopf family.
  • ドメインThe C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
  • 翻訳後修飾May be proteolytically processed by a furin-like protease.
  • 細胞内局在Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Dickkopf 2 antibody
    • Dickkopf gene 2 antibody
    • Dickkopf homolog 2 antibody
    • Dickkopf related protein 2 antibody
    • Dickkopf WNT signaling pathway inhibitor 2 antibody
    • Dickkopf-2 antibody
    • Dickkopf-related protein 2 antibody
    • Dickkopf2 antibody
    • DKK 2 antibody
    • Dkk-2 antibody
    • Dkk2 antibody
    • DKK2_HUMAN antibody
    • hDkk 2 antibody
    • hDkk-2 antibody
    • hDkk2 antibody
    see all

Anti-DKK2 antibody 画像

  • Lane 1 : Anti-DKK2 antibody (ab95274) at 4 µg/ml
    Lanes 2 - 4 : Anti-DKK2 antibody (ab95274) at 4 µg/ml (in 1X TBS/T with 5% nonfat milk, overnight at 4C.)

    Lane 1 : Jurkat cell lysate
    Lane 2 : Jurkat cell lysate
    Lane 3 : 3T3 cell lysate
    Lane 4 : Rat kidney tissue lysate

    Secondary
    Anti-rabbit conjugated secondary antibody

    Predicted band size : 28 kDa

Anti-DKK2 antibody (ab95274) 使用論文

ab95274 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab95274.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"