製品の概要

  • 製品名Anti-DIS antibody
    DIS 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to DIS
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat
    交差が予測される動物種: Cow, Dog, Human, Pig
  • 免疫原

    Synthetic peptide:

    RYCKERPSKDKE

    , corresponding to internal sequence (near C-Terminus) amino acids 901-912 of Human DIS (NP_060707.2).

  • ポジティブ・コントロール
    • Mouse and Rat skeletal muscle lysates

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab99282 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 120 kDa (predicted molecular weight: 133 kDa). An approximately 120 kDa band was observed in Mouse and Rat Skeletal Muscle lysates. An additional band of unknown identity was also consistently observed at 33 kDa. This band was successfully blocked by incubation with the immunizing peptide.

ターゲット情報

  • 機能Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation.
  • 組織特異性Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors.
  • 配列類似性Contains 1 SAP domain.
  • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Cytoplasm > perinuclear region.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CARP-1 antibody
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    • Death inducer with SAP domain antibody
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    see all

Anti-DIS antibody 画像

  • Anti-DIS antibody (ab99282) at 1 µg/ml + Rat skeletal muscle lysate in RIPA buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 133 kDa

Anti-DIS antibody (ab99282) 使用論文

ab99282 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"