製品の概要

  • 製品名Anti-DIS antibody
    DIS 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to DIS
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Dog, Turkey, Chimpanzee, Rhesus monkey, Gorilla, Tilapia, Orangutan
  • 免疫原

    Synthetic peptide within Human DIS aa 1-50. The exact sequence is proprietary.
    Database link: 55749

  • ポジティブ・コントロール
    • Human skin basal cell carcinoma and Mouse squamous cell carcinoma.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab84425 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/100 - 1/500.

Epitope exposure is recommended (exposure with citrate buffer will enhance staining). Likely to work with frozen sections.

ターゲット情報

  • 機能Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation.
  • 組織特異性Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors.
  • 配列類似性Contains 1 SAP domain.
  • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Cytoplasm > perinuclear region.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CARP-1 antibody
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    • Death inducer with SAP domain antibody
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Anti-DIS antibody 画像

  • ab84425, at 1/250 dilution, staining DIS in formalin-fixed, paraffin-embedded human skin basal cell carcinoma by Immunohistochemistry using DAB detection and an anti-Rabbit IgG HRP conjugated secondary antibody at a dilution of 1/100.
  • ab84425, at 1/250 dilution, staining DIS in formalin-fixed, paraffin-embedded mouse squamous cell carcinoma by Immunohistochemistry using DAB detection and an anti-Rabbit IgG HRP conjugated secondary antibody at a dilution of 1/100.

Anti-DIS antibody (ab84425) 使用論文

ab84425 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"