製品の概要

  • 製品名Anti-DIS antibody
    DIS 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to DIS
  • アプリケーション適用あり: WB, IPmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Dog, Chimpanzee, Rhesus monkey, Elephant
  • 免疫原

    Region between residue 1100 and the C terminus (residue 1150) of human DIS

  • ポジティブ・コントロール
    • Nuclear extract from HeLa cells

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab70245 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
IP
  • 追加情報IP: Use at 1-10µg/mg of lysate.
    WB: 1/1000 - 1/10000. Detects a band of approximately 132 kDa (predicted molecular weight: 132 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation.
    • 組織特異性Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors.
    • 配列類似性Contains 1 SAP domain.
    • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 細胞内局在Cytoplasm > perinuclear region.
    • Information by UniProt
    • 参照データベース
    • 別名
      • CARP-1 antibody
      • Carp1 antibody
      • Ccar1 antibody
      • CCAR1_HUMAN antibody
      • Cell cycle and apoptosis regulatory protein 1 antibody
      • cell division cycle and apoptosis regulator 1 antibody
      • Cell division cycle and apoptosis regulator protein 1 antibody
      • Death inducer with SAP domain antibody
      • FLJ10590 antibody
      • FLJ10839 antibody
      • FLJ13376 antibody
      • FLJ20734 antibody
      • MGC7730 antibody
      • RP11-437A18.1 antibody
      see all

    Anti-DIS antibody 画像

    • Lanes 1 - 2 : Anti-DIS antibody (ab70245) at 1 µg/ml
      Lanes 3 - 4 : Anti-DIS antibody (ab70245) at 0.2 µg/ml

      Lane 1 : Nuclear extract from HeLa cells at 15 µg
      Lane 2 : Nuclear extract from HeLa cells at 45 µg
      Lane 3 : Nuclear extract from HeLa cells at 15 µg
      Lane 4 : Nuclear extract from HeLa cells at 45 µg

      Developed using the ECL technique

      Predicted band size : 132 kDa
      Observed band size : 132 kDa


      Exposure time : 1 minute
    • Detection of Human CCAR1 by Immunoprecipitation using Nuclear extract (100 µg) from HeLa cells and Affinity purified rabbit anti-CCAR1 ab70245 at 1 µg/100 µg Nuclear extract. Chemiluminescence with exposure times of approximately 3 seconds.

    Anti-DIS antibody (ab70245) 使用論文

    ab70245 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"