製品の概要

  • 製品名DIDS
  • 製品の詳細
    Generic chloride channel blocker.
  • 別名
    • 4,4'-Diisothiocyano-2,2'-stilbenedisulfonic Acid, Disodium Salt
  • 生理活性の詳細

    Stilbene disulfonate that inhibits anionic transport. Used to inhibit Cl- uptake through plasma membrane-localized Cl- channels in order to study chloride transport. Also effectively inhibits various sodium-coupled bicarbonate transporters. Reacts with CD4 glycoprotein on T helper lymphocytes and macrophages, blocking HIV type-1 growth at multiple stages of the viral life cycle.

  • 特記事項

    Fluorescence: max. Abs. l = 341, max. Em. l = 415 (in water).

     

製品の特性

  • 体系名4,4'-Diisothiocyano-2,2'-stilbenedisulfonic acid disodium salt
  • 分子量498.50
  • 構造式Chemical Structure
  • 分子式C16H8N2Na2O6S4
  • CAS 番号67483-13-0
  • 保存方法Store at -20°C. Store at -20°C long term. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under Desiccating conditions.
  • 溶解性Soluble in DMSO and in water
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • 由来

    Synthetic

    DIDS (ab120277) 使用論文

    This product has been referenced in:
    • Pusch M  et al. Channel or transporter? The CLC saga continues. Exp Physiol 91:149-52 (2006). Read more (PubMed: 16179405) »
    • Picollo A  et al. Molecular determinants of differential pore blocking of kidney CLC-K chloride channels. EMBO Rep 5:584-9 (2004). Read more (PubMed: 15167890) »
    • Boron WF Sodium-coupled bicarbonate transporters. JOP 2:176-81 (2001). Read more (PubMed: 11875256) »
    • Horie S  et al. Effects of 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid, an inhibitor of Cl(-)-HCO3- exchanger, on stress-induced gastric lesions in rats. Res Commun Chem Pathol Pharmacol 79:117-20 (1993). Read more (PubMed: 8434127) »
    • Mayinger P & Meyer DI An ATP transporter is required for protein translocation into the yeast endoplasmic reticulum. EMBO J 12:659-66 (1993). Read more (PubMed: 8440256) »
    • Cardin AD  et al. Stilbene disulfonic acids. CD4 antagonists that block human immunodeficiency virus type-1 growth at multiple stages of the virus life cycle. J Biol Chem 266:13355-63 (1991). Read more (PubMed: 2071607) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"