製品の概要

  • 製品名Diclofenac sodium salt
  • 製品の詳細
    Potent cyclo-oxygenase inhibitor
  • 生理活性の詳細Potent non-selective COX inhibitor (IC50 values are 75 and 29 nM at COX-1 and COX-2, respectively). Potent inhibitor of phospholipase A2 in vitro and in vivo. Activates the nitric oxide-cyclic GMP-potassium channel pathway. Shows anti-inflammatory, antipyretic and analgesic effects.
  • 精製度> 99%

製品の特性

    アプリケーション

    Our Abpromise guarantee covers the use of ab120621 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    アプリケーション Abreviews 特記事項
    Functional Studies Use at an assay dependent concentration.

    Diclofenac sodium salt 画像

    • ab96732 staining Prostaglandin dehydrogenase 1 in MCF7 cells treated with diclofenac sodium salt (ab120621), by ICC/IF. Increase in Prostaglandin dehydrogenase 1 expression correlates with increased concentration of diclofenac sodium salt as described in literature.
      The cells were incubated at 37°C for 6h in media containing different concentrations of ab120621 (diclofenac sodium salt) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab96732 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.

    Diclofenac sodium salt (ab120621) 使用論文

    This product has been referenced in:
    • León-Reyes MR  et al. Pharmacokinetics and pharmacodynamics of diclofenac in the presence and absence of glibenclamide in the rat. J Pharm Pharm Sci 11:68-76 (2008). Read more (PubMed: 18801308) »
    • Warner TD  et al. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci U S A 96:7563-8 (1999). Read more (PubMed: 10377455) »
    • Mäkelä A  et al. Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro. Scand J Clin Lab Invest 57:401-7 (1997). Read more (PubMed: 9279965) »
    • Scholer DW  et al. Pharmacology of diclofenac sodium. Am J Med 80:34-8 (1986). Read more (PubMed: 3085490) »

    See 0 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab120621.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"