製品の概要

  • 製品名Anti-DFNB31 antibody
    DFNB31 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to DFNB31
  • 特異性ab106980 will not recognise isoform 2.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 385-413 of Human DFNB31 (NP_056219.3, NP_001077354.2, NP_001166896.1).

  • ポジティブ・コントロール
    • K562 cell lysate.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)Purified through a protein A column, followed by peptide affinity purification.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab106980 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 97 kDa.

ターゲット情報

  • 機能Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear.
  • 関連疾患Defects in WHRN are the cause of deafness autosomal recessive type 31 (DFNB31) [MIM:607084]. DFNB31 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
    Defects in WHRN are the cause of Usher syndrome type 2D (USH2D) [MIM:611383]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH2 is characterized by congenital mild hearing impairment with normal vestibular responses.
  • 配列類似性Contains 3 PDZ (DHR) domains.
  • 細胞内局在Cytoplasm. Cell projection > stereocilium. Cell projection > growth cone. Detected at the level of stereocilia in inner outer hair cells of the cochlea and vestibule. Co-localizes with the growing ends of actin filaments (By similarity). Colocalizes with MPP1 in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies and at the connecting cilium.
  • Information by UniProt
  • 参照データベース
  • 製品の状態There are 4 isoforms produced by alternative splicing.
  • 別名
    • 1110035G07Rik antibody
    • Autosomal recessive deafness type 31 protein antibody
    • CASK interacting protein CIP98 antibody
    • CIP 98 antibody
    • CIP98 antibody
    • Deafness autosomal recessive 31 antibody
    • DFNB 31 antibody
    • DKFZp434N014 antibody
    • KIAA1526 antibody
    • RP11 9M16.1 antibody
    • USH 2D antibody
    • USH2D antibody
    • Whirlin antibody
    • WHRN antibody
    • WHRN_HUMAN antibody
    • WI antibody
    see all

Anti-DFNB31 antibody 画像

  • Anti-DFNB31 antibody (ab106980) at 1/100 dilution + K562 cell lysate at 35 µg

    Predicted band size : 97 kDa

Anti-DFNB31 antibody (ab106980) 使用論文

ab106980 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"