製品の概要

  • 製品名
    Anti-Desmoglein 2 antibody - N-terminal
    Desmoglein 2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Desmoglein 2 - N-terminal
  • アプリケーション
    適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide (Human) conjugated to KLH, from the N-terminal region of human Desmoglein 2.

  • ポジティブ・コントロール
    • T47D cell line lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab76668 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/50 - 1/100. Detects a band of approximately 122 kDa (predicted molecular weight: 122 kDa).
ELISA 1/1000.

ターゲット情報

  • 機能
    Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
  • 組織特異性
    All of the tissues tested and carcinomas.
  • 関連疾患
    Defects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia type 10 (ARVD10) [MIM:610193]; also known as arrhythmogenic right ventricular cardiomyopathy 10 (ARVC10). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
    Genetic variations in DSG2 are the cause of susceptibility to cardiomyopathy dilated type 1BB (CMD1BB) [MIM:612877]. A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
  • 配列類似性
    Contains 4 cadherin domains.
  • ドメイン
    Calcium may be bound by the cadherin-like repeats.
  • 細胞内局在
    Cell membrane. Cell junction > desmosome.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ARVC 10 antibody
    • ARVC10 antibody
    • ARVD 10 antibody
    • ARVD10 antibody
    • Cadherin family member 5 antibody
    • CDHF 5 antibody
    • CDHF5 antibody
    • CMD1BB antibody
    • Desmoglein 2 antibody
    • Desmoglein-2 antibody
    • Desmoglein2 antibody
    • DSG 2 antibody
    • DSG2 antibody
    • DSG2_HUMAN antibody
    • HDGC antibody
    • HDGC included antibody
    • Human Desmoglein colon antibody
    • MGC117034 antibody
    • MGC117036 antibody
    • MGC117037 antibody
    see all

画像

  • Anti-Desmoglein 2 antibody - N-terminal (ab76668) at 1/50 dilution + T47D cell lysate at 35 µg

    Predicted band size : 122 kDa
    Observed band size : 122 kDa

プロトコール

参考文献

This product has been referenced in:
  • Resnik N  et al. Desmosome assembly and cell-cell adhesion are membrane raft-dependent processes. J Biol Chem 286:1499-507 (2011). WB ; Dog . Read more (PubMed: 21071449) »
  • Lokar M  et al. Protruding membrane nanotubes: attachment of tubular protrusions to adjacent cells by several anchoring junctions. Protoplasma 246:81-7 (2010). ICC/IF ; Human . Read more (PubMed: 20526853) »

See all 2 Publications for this product

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