製品の概要

  • 製品名Anti-Desmocollin 2 antibody
    Desmocollin 2 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to Desmocollin 2
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Recombinant Fragment
    交差が予測される動物種: Human, Chimpanzee, Rhesus monkey
  • 免疫原

    Recombinant fragment: SREASPRSAM STATVTVNVE DQDEGPECNP PIQTVRMKEN AEVGTTSNGY KAYDPETRSS SGIRYKKLTD PTGWVTIDEN TGSIKVFRSL D, corresponding to amino acids 444-535 of Human Desmocollin 2 (NP_077740) with tag.

  • ポジティブ・コントロール
    • Recombinant tagged human Desmocollin 2 fragment.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab76628 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
  • 追加情報ELISA: Use at an assay dependent dilution.
    WB: Use at a concentration of 1 - 5 µg/ml. Predicted molecular weight: 100 kDa.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
    • 組織特異性Expressed in epithelia, myocardium and lymph nodes.
    • 関連疾患Defects in DSC2 are the cause of familial arrhythmogenic right ventricular dysplasia type 11 (ARVD11) [MIM:610476]; also known as arrhythmogenic right ventricular cardiomyopathy 11 (ARVC11). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
    • 配列類似性Contains 5 cadherin domains.
    • ドメインCalcium may be bound by the cadherin-like repeats.
    • 細胞内局在Cell membrane. Cell junction > desmosome.
    • Information by UniProt
    • 参照データベース
    • 別名
      • ARVD11 antibody
      • Cadherin family member 2 antibody
      • CDHF2 antibody
      • Desmocollin 3 antibody
      • Desmocollin-2 antibody
      • Desmocollin-3 antibody
      • Desmocollin2 antibody
      • Desmosomal glycoprotein II and III antibody
      • Desmosomal glycoprotein II antibody
      • Desmosomal glycoprotein II/III antibody
      • Desmosomal glycoprotein III antibody
      • DG2 antibody
      • DGII/III antibody
      • DKFZp686I11137 antibody
      • DSC 2 antibody
      • DSC2 antibody
      • DSC2_HUMAN antibody
      • DSC3 antibody
      see all

    Anti-Desmocollin 2 antibody 画像

    • Anti-Desmocollin 2 antibody (ab76628) at 1 µg/ml + Recombinant tagged human Desmocollin 2 fragment at 0.2 µg

      Secondary
      Goat Anti-Mouse IgG (H&L)-HRP at 1/5000 dilution

      Predicted band size : 100 kDa
      Observed band size : 37 kDa (why is the actual band size different from the predicted?)

    Anti-Desmocollin 2 antibody (ab76628) 使用論文

    ab76628 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab76628.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"