製品の概要

  • 製品名Anti-DERL1 antibody
    DERL1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to DERL1
  • アプリケーション適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Recombinant Fragment
    交差が予測される動物種: Mouse, Human
  • 免疫原

    Synthetic peptide corresponding to N-terminal residues of human DERL1.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.01% Sodium Azide
    Constituents: 50% Glycerol, PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab54545 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA Use at an assay dependent dilution.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 29 kDa. for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.

ターゲット情報

  • 関連性Derlin 1 is a channel-like protein found in the endoplasmic reticulum (ER) membrane. It is specifically required for the degradation of misfolded ER luminal proteins. Derlin 1 participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. It may act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol and then transferring them to the ATPase VCP complex, which translocates and ubiquitinates misfolded proteins. In the case of infection by cytomegaloviruses, derlin 1 plays a central role in export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Derlin 1 also participates in the degradation of misfolded cytomegalovirus US2 protein.
  • 細胞内局在Endoplasmic reticulum; multi pass membrane protein.
  • 参照データベース
  • 別名
    • DER 1 antibody
    • DER1 antibody
    • Der1 like protein 1 antibody
    • DERL 1 antibody
    • Derlin 1 antibody
    • DERtrin 1 antibody
    see all

Anti-DERL1 antibody (ab54545) 使用論文

ab54545 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"