Anti-Deoxyguanosine kinase 抗体 (ab60152)


  • 製品名Anti-Deoxyguanosine kinase antibody
    Deoxyguanosine kinase 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Deoxyguanosine kinase
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    KLH conjugated synthetic peptide from the N-terminal region of human Deoxyguanosine kinase.

  • ポジティブ・コントロール
    • Kidney lysate


  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度Protein G purified
  • 特記事項(精製)Purified through a protein G column, eluted with both high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野


Our Abpromise guarantee covers the use of ab60152 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/50 - 1/500. Detects a band of approximately 32 kDa (predicted molecular weight: 32 kDa).
ELISA 1/1000.


  • 関連性Mitochondrial deoxyguanosine kinase (DGUOK) is required for the phosphorylation of several deoxyribonucleosides and certain purine deoxykribonucleoside analogs widely employed as antiviral and chemotherapeutic agents. Purine deoxyribonucleoside analogs are extensively used in treatment of lymphoproliferative disorders. These compounds are administered as pro-drugs, and their efficiency is dependent on intracellular phosphorylation to the corresponding triphosphates. In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by 2 deoxyribonucleoside kinases: cytosolic deoxycytidine kinase (DCK) and mitochondrial deoxyguanosine kinase (DGUOK also known as DGK). DGUOK expression is ubiquitous, with highest levels in muscle, brain, liver and lymphoid tissues. Defects in DGUOK are a cause of mitochondrial DNA depletion syndrome (MDS). MDS is a clinically heterogeneous group of disorders characterized by a reduction in mitochondrial DNA (mtDNA) copy number. Primary mtDNA depletion is inherited as an autosomal recessive trait and may affect single organs, typically muscle or liver, or multiple tissues. Mitochondrial DNA depletion syndromes are phenotypically heterogeneous, autosomal recessive disorders characterized by tissue-specific reduction in mtDNA copy number. Affected individuals with the hepatocerebral form of mtDNA depletion syndrome have early progressive liver failure and neurologic abnormalities, hypoglycemia, and increased lactate in body fluids.
  • 参照データベース
  • 別名
    • Deoxyguanosine kinase mitochondrial antibody
    • dGK antibody
    • DGUOK antibody

Anti-Deoxyguanosine kinase antibody 画像

  • Anti-Deoxyguanosine kinase antibody (ab60152) at 1/60 dilution + Mouse kidney tissue lysate at 35 µg

    Predicted band size : 32 kDa
    Observed band size : 32 kDa

Anti-Deoxyguanosine kinase antibody (ab60152) 使用論文

ab60152 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab60152.
Please use the links above to contact us or submit feedback about this product.