製品の概要

  • 製品名Anti-DENN antibody
    DENN 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to DENN
  • アプリケーション適用あり: ICC/IF, WBmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Synthetic peptide corresponding to Human DENN aa 1570-1588.
    Sequence:

    AAVHSSEEDLRTPPRPVSS


    (Peptide available as ab8384)

  • ポジティブ・コントロール
    • HeLa whole cell lysate or 3T3 whole cell lysate.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab2043 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use a concentration of 10 µg/ml.
WB 1/250 - 1/500. Predicted molecular weight: 220 kDa.Can be blocked with DENN peptide (ab8384).

ターゲット情報

  • 機能Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect.
  • 組織特異性Highly expressed in fetal brain and kidney; adult testis, ovary, brain and heart. Isoform 5 is constitutively expressed in all tissues. Isoform 7 is expressed in fetal liver and in several cancer cell lines.
  • 配列類似性Belongs to the MADD family.
    Contains 1 dDENN domain.
    Contains 1 death domain.
    Contains 1 DENN domain.
    Contains 1 uDENN domain.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Differentially expressed in normal and neoplastic cells antibody
    • FLJ35600 antibody
    • IG20 antibody
    • Insulinoma glucagonoma clone 20 antibody
    • KIAA0358 antibody
    • MADD antibody
    • MADD_HUMAN antibody
    • MAP kinase-activating death domain protein antibody
    • Rab3 GDP/GTP exchange factor antibody
    • RAB3GEP antibody
    see all

Anti-DENN antibody 画像

  • All lanes : Anti-DENN antibody (ab2043) at 1/250 dilution

    Lane 1 : Hela whole cell lysate
    Lane 2 : A431 whole cell lysate
    Lane 3 : K562 whole cell lysate
    Lane 4 : NIH3T3 whole cell lysate


    Predicted band size : 220 kDa
  • ab2043 at 10µg/ml staining DENN in human spleen tissue by ICC
  • Immunofluorescence of MADD in Hela cells using ab2043 at 20 ug/ml.

Anti-DENN antibody (ab2043) 使用論文

ab2043 has not yet been referenced specifically in any publications.

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